Electromagnetic and acoustic technologies in antibacterial preparation development

O. Kovalenko, S. Kalinichenko, E. Babich, F. Kivva, O. Roenko, T. Antusheva
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Abstract

Subject and Purpose. The present paper is concerned with the use of wave technologies in the development of antibiotics-alternative approaches for pathogenic microflora suppression. Lactobacilli strains picked in different ecological niches and their activity against pathogenic strains are studied with a focus on a targeted modification of adhesive and antagonistic properties of lactobacilli by exposing them to low-intensity electromagnetic (EM) fields and the ultrasound. Methods and Methodology. Lactobacilli picked in different ecological niches are experimentally studied, including (1) standard strains from probiotic preparations and (2) circulating strains picked in humans and bees. For the ultrasonic and electromagnetic radiation sources, G3-109 and G3-F and G4-141 and G4-142 generators are taken, respectively. The adhesive properties of Lactobacillus spp. strains and their antagonistic activity are estimated against C. diphtheriae, S. aureus and yeast-like fungi of Candida genus in aerobic and microaerophilic culture conditions. Statistical technology is employed in the data processing and analysis. Results. It has been established that L. plantarum strains picked in the gut of healthy bees are most antagonistic towards pathogens. It has been demonstrated that the priority culture conditions for lactobacilli are microaerophilic conditions simulating their stay in vivo. It has been shown that it is possible to modify properties of microorganisms by their exposure to ultrasound and low-intensity electromagnetic fields in narrow bands of the EHF range. The effect efficiency versus frequency has a dispersion character. Individual features of various pathogenic strains have been recognized. Conclusion. The obtained results open up prospects for electromagnetic and acoustic technologies in the development of safe alternative means to antagonize persisting pathogens and increase human body resilience.
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电磁与声学技术在抗菌制剂中的应用
主题和目的。本文关注的是利用波浪技术开发抗生素替代方法来抑制病原微生物群。研究了不同生态位的乳酸菌菌株及其对病原菌的活性,重点研究了低强度电磁场和超声对乳酸菌粘附和拮抗特性的靶向修饰。方法和方法论。实验研究了在不同生态位中挑选的乳酸菌,包括(1)益生菌制剂中的标准菌株和(2)在人类和蜜蜂中挑选的循环菌株。超声波辐射源和电磁辐射源分别取G3-109和G3-F发生器,取G4-141和G4-142发生器。研究了乳酸菌菌株在好氧和嗜微氧培养条件下对白喉双歧杆菌、金黄色葡萄球菌和念珠菌属酵母样真菌的粘附性能和拮抗活性。在数据处理和分析中采用了统计技术。结果。已经确定,在健康蜜蜂肠道中采摘的植物乳杆菌菌株对病原体最具拮抗作用。研究表明,乳酸杆菌的优先培养条件是模拟其在体内停留的微嗜气条件。研究表明,在EHF范围的狭窄波段内,微生物暴露于超声波和低强度电磁场中,可以改变其特性。效应效率随频率的变化具有色散特性。各种致病菌株的个体特征已得到确认。结论。所获得的结果为电磁和声学技术在开发对抗持续存在的病原体和增加人体恢复力的安全替代手段方面开辟了前景。
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