"Imageable" Zinc-Silicate Glass Microspheres For Transarterial Embolization: A Renal Artery Embolization Study.

Q1 Materials Science Biomedical Glasses Pub Date : 2015-08-26 DOI:10.1515/bglass-2015-0007

S. Kehoe, Salma Amensag, M. Looney, R. Abraham, D. Boyd

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引用次数: 5

Abstract

Abstract Intrinsically radiopaque (imageable) microspheres for transarterial embolization (TAE) are required to enable real-time intraprocedural feedback and definition of spatial distribution patterns of embolic materials in target tissues. This pilot study evaluates acute and sub-chronic safety and efficacy of imageable zinc-silicate (Zn-Si) glass microspheres in a swine renal artery embolization (RAE) model. Eight swine were divided into two cohorts. Clinical determinants of embolization effectiveness, including imageability, deliverability and temporal/ spatial distribution of microspheres in target tissues were assessed. Subsequently, cohort I and II were used to evaluate the acute and subchronic host response against the Zn-Si microspheres versus a clinical control. The developed microspheres provide for direct intraprocedural feedback using standard diagnostic imaging techniques. Fluoroscopy correlated with ex-vivo high-resolution radiography, CT and micro-CT, demonstrating high imageability, excellent spatial distribution and packing of the Zn- Si microspheres. At follow-up, infarction of the embolized kidneys was noted without any major adverse tissue reaction. Mild recanalization was observed microscopically for both experimental and control microspheres. Zn-Si microspheres permit the definition of spatial distribution in a target tissue, consequently permitting the optimization, personalization and improvement of TAE techniques.

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“可成像”的锌硅酸盐玻璃微球经动脉栓塞:肾动脉栓塞研究。

经动脉栓塞(TAE)需要本质不透射线(可成像)的微球，以实现实时术中反馈和靶组织中栓塞材料空间分布模式的定义。本初步研究评估了可成像硅酸锌(Zn-Si)玻璃微球在猪肾动脉栓塞(RAE)模型中的急性和亚慢性安全性和有效性。八头猪被分成两组。评估栓塞效果的临床决定因素，包括靶组织中微球的可成像性、可输送性和时间/空间分布。随后，队列I和II被用来评估急性和亚慢性宿主对锌硅微球的反应与临床对照。开发的微球使用标准诊断成像技术提供直接的术中反馈。透视检查与离体高分辨率x线摄影、CT和微CT相关联，显示出Zn- Si微球的高可成像性、良好的空间分布和填充性。在随访中，栓塞肾脏的梗死被注意到没有任何主要的不良组织反应。实验微球和对照微球在显微镜下均观察到轻微的再通化。锌硅微球允许在目标组织中定义空间分布，从而允许TAE技术的优化，个性化和改进。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.