Bioactivity of toothpaste containing bioactive glass in remineralizing media: effect of fluoride release from the enzymatic cleavage of monofluorophosphate.

Q1 Materials Science Biomedical Glasses Pub Date : 2015-07-21 DOI:10.1515/bglass-2015-0005
Anthony L. B. Maçon, Esther Valliant, J. Earl, Julian R. Jones
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引用次数: 7

Abstract

Abstract Objectives. The aim was to introduce a new methodology to characterize toothpaste containing bioactive glass and to evaluate the effect of release of fluoride ions, by cleaving monofluorophosphate (MFP), on the mineral forming ability of Sensodyne Repair & Protect (SRP). which contains NovaMinTM (bioactive glass, 45S5 composition). Methods. SRP, NovaMin particles, and placebo paste (PLA) which did not contain NovaMin, were immersed into a remineralization media (RS), which mimics the ionic strength of human saliva, for 3 days with different concentrations of alkaline phosphatase (ALP): 0, 25 and 75 U.L−1. Ion concentration profiles and pH were monitored by ICPOES and F− ion selective electrode. Remaining solids were collected by freeze-drying and their surfaces analysed. Results. Hydroxyapatite (HA) formed on the surface of BG alone (after 1 h) and in toothpaste (after 2 h), whereas PLA did not induce any precipitation. ALP cleaved MFP at different rates depending on the enzyme concentration. Increasing the concentration of ALP from 0 and 75 U.L−1 reduced the time of HA formation from 2 h to 24 h. However, the presence of fluoride induced the precipitation of fluorapatite. No evidence of fluorite (CaF2) was observed. The apatite formation ability of toothpaste can be assessed using the presented method.
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含生物活性玻璃牙膏在再矿化介质中的生物活性:单氟磷酸盐酶解释放氟的影响。
抽象的目标。目的是介绍一种新的方法来表征含有生物活性玻璃的牙膏,并评估通过切割单氟磷酸盐(MFP)释放氟离子对Sensodyne修复与保护(SRP)矿物形成能力的影响。其中含有NovaMinTM(生物活性玻璃,45S5成分)。方法。将SRP、NovaMin颗粒和不含NovaMin的安慰剂膏体(PLA)浸入模拟人唾液离子强度的再矿化培养基(RS)中3天,碱性磷酸酶(ALP)浓度分别为0、25和75 U.L−1。用ICPOES和F -离子选择电极监测离子浓度分布和pH值。通过冷冻干燥收集剩余固体,并对其表面进行分析。结果。羟基磷灰石(HA)在单独BG表面(1h后)和牙膏中(2h后)形成,而PLA没有诱导任何沉淀。ALP对MFP的裂解速率取决于酶的浓度。当ALP浓度从0到75 μ l−1增加时,HA的形成时间从2 h缩短到24 h。然而,氟的存在诱导了氟磷灰石的沉淀。没有观察到萤石(CaF2)的证据。用该方法可以评价牙膏的磷灰石形成能力。
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
0.00%
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审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
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