Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Q1 Materials Science Biomedical Glasses Pub Date : 2015-07-29 DOI:10.1515/bglass-2015-0006
P. Balasubramanian, L. Strobel, U. Kneser, A. Boccaccini
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引用次数: 65

Abstract

Abstract Zinc is a vital and beneficial trace element found in the human body. Though found in small proportions, zinc performs a variety of functions in relation to the immune system, cell division, fertility and the body growth and maintenance. In particular, zinc is proven to be a necessary element for the formation, mineralization, development and maintenance of healthy bones. Considering this attractive attributes of zinc, recent research has widely focused on using zinc along with silicate-based bioactive glasses for bone tissue engineering applications. This paper reviews relevant literature discussing the significance of zinc in the human body, along with its ability to enhance antibacterial effects, bioactivity and distinct physical, structural and mechanical properties of bioactive glasses. In this context, even if the present analysis is not meant to be exhaustive and only representative studies are discussed, literature results confirm that it is essential to understand the properties of zinc-containing bioactive glasses with respect to their in vitro biological behavior, possible cytotoxic effects and degradation characteristics to be able to effectively apply these glasses in bone regeneration strategies. Topics attracting increasing research efforts in this field are elaborated in detail in this review, including a summary of the structural, physical, biological and mechanical properties of zinc-containing bioactive glasses. This paper also presents an overview of the various applications in which zinc-containing bioactive glasses are considered for use as bone tissue scaffolds, bone filling granules, bioactive coatings and bone cements, and advances and remaining challenges are highlighted.
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含锌生物活性眼镜用于骨再生,牙科和骨科应用
锌是人体中一种重要而有益的微量元素。虽然锌的含量很少,但它在免疫系统、细胞分裂、生育能力和身体生长和维持方面发挥着多种功能。特别是,锌被证明是形成、矿化、发育和维护健康骨骼的必要元素。考虑到锌的这些吸引人的特性,最近的研究广泛关注于将锌与硅酸盐基生物活性玻璃一起用于骨组织工程。本文综述了相关文献,讨论了锌在人体中的重要性,以及锌在增强抗菌作用、生物活性和生物活性玻璃中独特的物理、结构和力学性能方面的作用。在这种情况下,即使目前的分析并不详尽,只讨论了具有代表性的研究,文献结果证实,了解含锌生物活性玻璃的性质及其体外生物学行为、可能的细胞毒性作用和降解特征是至关重要的,以便能够有效地将这些玻璃应用于骨再生策略。本文就含锌生物活性玻璃的结构、物理、生物和力学性能等方面的研究进展进行了综述。本文还概述了含锌生物活性玻璃在骨组织支架、骨填充颗粒、生物活性涂层和骨水泥等方面的各种应用,并重点介绍了含锌生物活性玻璃的研究进展和面临的挑战。
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
0.00%
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审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
期刊最新文献
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