Chitosan based hydrogels and their use in medicine

Abstract

Chitosan is a natural biopolymer, polysaccharide, a product of chitin deacetylation. Chitosan is a non-toxic, biocompatible and biodegradable polymer with high biological activity and stability in the environment. In addition, chitosan is obtained from natural renewable resources and is an inexpensive substance. Due to all these properties, chitosan is widely used in practical medicine, for example, in the form of hydrogel dosage forms in combination with natural and synthetic polymers. This review is focused on polymer hydrogel materials based on chitosan. Special attention is paid to the preparation and use of wound dressings for the treatment of wounds of various etiologies. The use of hydrogel wound dressings based on this polysaccharide allows to create a protective shell on the surface of various wounds, to prolong delivery of antibacterial agents, peptides and other active substances, which significantly increases the effectiveness of therapy. Bactericidal and sorption properties of chitosan-based hydrogels established in experimental and clinical studies are discussed.