An antioxidant approach directed to non-healing wounds activation - A case report study

Abstract

It is well known that oxidative stress is a pathologic condition that compromises wound evolution, contributing to inflammatory environment maintaining and wound healing stagnation. This condition specially affects to aged people and to patients with important comorbidities, whereby healing capabilities are significantly impaired. In this work, a new therapeutic approach through a new antioxidant technology with natural components has been applied, in order to manage the oxidative stress, in 31 patients with complex chronic wounds of different etiologies, attended to the Sanitary West District in Almería (Spain). Wound assessments were performed at 4, 8 and 12 weeks and main endpoints included the evolution of wound healing (% of healing rate and Resvech 2.0 score) and pain relief. The treatment with antioxidant dressing produced a significant decrease of RESVECH 2.0 of 37.28%, 58.52% and 67.8% at 4, 8 and 12 weeks respectively and during the 12 week follow-up, 16/31 wounds totally healed (50%). In addition, a decrease in pain and biofilm presence in wounds were observed. In conclusion, the analyzed antioxidant approach could be a new therapeutic strategy directed to overcome the inflammatory phase in complex wounds and allow the progression over the healing process.