MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL

Abstract

Purpose: Gastroenteropancreatic neuroendocrine tumors are heterogeneous group of tumors. The pathomorphological assessment is essential for the staging and requires an immunohistochemical panel of several markers for validation.The aim of the article is to summarize pathological constellation for neuroendocrine tumor and immunohistochemical panel. Methods: Critical evaluation of the data available from existing studies. Results: Current immunohistochemical diagnostic markers include synaptophysin, chromogranin, and Ki-67 index. The ability of SSRs to be internalized in the development of radiolabeled somatostatin analogues has further contributed to improved diagnosis and treatment of NETs. Conclusion: Nowadays, there has been a significant increase in the number of molecularly targeted agents in the treatment of neuroendocrine tumors.