S. Cacciapuoti, C. Marasca, M. Luciano, A. Masarà, M. Donnarumma, A. Balato, G. Fabbrocini
{"title":"mTOR in inflammatory skin diseases: Review of the literature and our experience","authors":"S. Cacciapuoti, C. Marasca, M. Luciano, A. Masarà, M. Donnarumma, A. Balato, G. Fabbrocini","doi":"10.15761/JTS.1000317","DOIUrl":null,"url":null,"abstract":"The mTORC1 protein complex consists of multiple components such as the serine/threonine kinase mTOR and the regulatoryassociated protein of mTOR (Raptor). Three highly researched upstream modulators of mTOR are the phosphatidylinositol 3-kinases (PI3Ks), protein kinase B (Akt). PI3K, and tumor necrosis factor alpha (TNFa) regulates Akt. Increased expression of PI3K, Akt, and TNFa amplifies mTORC1 activity as well (Figure 1) [3,4].","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of translational science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/JTS.1000317","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The mTORC1 protein complex consists of multiple components such as the serine/threonine kinase mTOR and the regulatoryassociated protein of mTOR (Raptor). Three highly researched upstream modulators of mTOR are the phosphatidylinositol 3-kinases (PI3Ks), protein kinase B (Akt). PI3K, and tumor necrosis factor alpha (TNFa) regulates Akt. Increased expression of PI3K, Akt, and TNFa amplifies mTORC1 activity as well (Figure 1) [3,4].
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