Journal of translational science最新文献

Background: The Mountain West Clinical and Translational Research Infrastructure Network (MW-CTR-IN) promotes junior investigators' careers via robust mentorship and faculty development. A key success indicator is the diversity and volume of scholarly publications. We employed scientometric methods to evaluate both database and non-database outputs-including academic works not traditionally indexed in bibliographic databases-over ten years, examining publication types, thematic focuses, and factors such as gender and discipline.

Methods: We analyzed 1,554 peer-reviewed publications (1,141 from databases and 413 from non-database sources) published between 2014 and 2024. Publications were categorized by type and translational research stage using predefined criteria. Two independent coders classified the manuscripts. Gender and discipline differences were assessed.

Results: From 2014 to 2024, 1,554 peer-reviewed publications were documented-1,141 database articles (68%) and 413 (31%) non-database outputs. Notably, publication numbers nearly doubled between 2020 and 2022 compared to previous years. Early database publications primarily focused on T0 and T1 levels (preclinical and basic research). In contrast, later years (2020, 2022, and 2023) saw significant growth in T3 and T4 research, indicating a shift toward advanced translational efforts. Males predominated in basic science (28% vs. 14%, p < .001).

Conclusions: Rising publication trends underscore MW-CTR-IN's success in building junior research capacity and reveal the remarkable impact of both traditional and non-traditional scholarly outputs in guiding equitable, interdisciplinary training. The inclusion of non-database publications-such as guidelines, protocols, and technical innovations-offers a more comprehensive evaluation of academic productivity and translational impact.

Background: Clinical research is a central mission of the University of Colorado Anschutz Medical Campus (CU-Anschutz). On March 18, 2020, due to rising COVID-19 rates and personal protective equipment (PPE) shortages, an emergency approval process for critical research essential to the care and safety of patients, including COVID-19 trials, was enacted. All other clinical research studies requiring face-to-face visits were placed on hold to protect participant and staff safety.

Methods: A clinical research TaskForce was rapidly assembled, consisting of a cross- section of campus clinical research operations leaders, including affiliate hospitals. This group developed a guidance document and process where the primary prioritization factor was positive therapeutic benefit/risk (Groups 2-5). A REDCap form demarcating items including research visit types and safety plans was designed. A separate Space Plan Committee approval was required to gauge environmental health and safety.

Results: A total of 654 protocols were approved over 31 weeks using this process. Group 2 review and approvals occurred within 5 days of campus reactivation, and 65 days after original clinical research hold. Groups 3 through 5 were opened for submission and review in a phased approach. The majority proactively submitted IRB protocol amendments to minimize face-to-face participant/staff contact. There were no cases of COVID-19 outbreak in research participants.

Conclusion: Clinical research reactivation was rapidly implemented in a transparent, collaborative, broadly supported, and efficient process of staged reactivation while prioritizing the health and safety of participants and staff at CU-Anschutz. This model is practical and easily generalizable to other medical research campuses.

Although HSV-1 has been implicated in facial palsy for a long time, testing and treating for HSV is not routine. The lack of a meaningful demonstration of how HSV-1 would cause facial palsy has limited progress in this field. Herein we demonstrate that the depth of the lip HSV-1 infection defines the course of the disease, with deeper subcutaneous infection allowing virus access to the facial nerve and causing facial palsy. HSV-1 inoculated subcutaneously caused extensive facial paralysis in cotton rats Sigmodon hispidus, while virus inoculated in the same area of the lip by skin surface abrasion did not. Demyelination along the facial nerve (CN VII) accompanied subcutaneous HSV-1 infection and was identified as the possible underlying mechanism of the disease. This causality demonstration is particularly important in light of increased facial palsy outbreaks associated with SARS-CoV-2 infection and SARS-CoV-2 and influenza vaccinations.