SYNTHESIS and ANTIMICROBIAL ACTIVITY of SOME NOVEL QUINOXALINE HYDRAZONES

Esra Başyiğit, U. A. Çevik, Y. Özkay, Hülya Karaca Gençer, Ü. Uçucu
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Abstract

10 yeni kinoksalin hidrazondan olusan yeni bir grup aktimikrobiyal aktivitesi incelenmek uzere sentezlenmistir. Bilesiklerin yapilari IR, 1H-NMR, MS spektral ve elemental analiz ile aydinlatilmistir. Bilesiklerin antimikrobiyal aktiviteleri Mikro-broth dilusyon yontemi ile 3 fungus ve 7 bakteri turune karsi degerlendirilmistir. Sentezlenen butun bilesikler Pseudomonas aeruginosa’ ya karsi onemli antibakteriyal aktivite gostermistir. Ayrica, 2,4-difloro yapisi iceren 4b bilesigi Pseudomonas aeruginosa’ ya karsi kloramfenikolden 2 kat daha iyi antibakteriyal aktivite gostermistir
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几种新型喹诺啉腙的合成及抗菌活性研究
如果你有10个新的kinoxalin氢,一组新的活性微生物活性将被分离浓缩。通过IR、1H-NMR、MS光谱和元素分析突出了科学结构。科学家的抗菌活性已被3种真菌和7种细菌火鸡在微细菌稀释液中降解。铜绿假单胞菌对胃肠道的抗菌活性具有高度毒性。此外,2.4-二氟代产生的4倍塑料铜绿假单胞菌加氯芬尼可产生比氯芬尼高2倍的抗菌活性
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