CITRULLUS COLOCYNTHIS FRUIT EXTRACT AS AN ANTI-DEPRESSANT IN MICE

Nafisi Saeed, Rezazadeh Leila, Hosseini Ehsan, Shamsizadeh Morteza, Bahrami Mousavi Anwar, B. Mohammad
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引用次数: 2

Abstract

Introduction: Depression has multifactorial characters including brain-behavioral disorders, alteration in cognitive psychomotor and emotional process. Millions of people are worldwide suffering from this illness. This disease happens in all ages of men and women. This research tries to introduce a traditional medication in comparison with common chemical antidepressant drugs. This experiment was designed to evaluate probably the antidepressant effect of Citrullus colocynthis fruit extraction. Materials and methods: Thirty-two male mice (Balb/c) was randomly divided to four groups (n=8 each). Animals adapted and treated to diazepam, imipramine, aqueous and hydro alcoholic extract of Citrullus colocynthis fruit. All administrations were done via intraperitoneal 0.2ml/animal. Plant material after grinding was extracted with ethanol and evaporated under reduced pressure. Tail suspension test was carried out to assay the antidepressant effect of plant extraction in animals. The test was carried on before, and as well as 30, 60 and 120 minutes after injections. Results: Our data indicated that after intraperitoneal administration of aqueous and ethanol extract, immobility duration exhibits statistically significant increase compared to agitation phase in all times after injection(P<0.05). Ethanol extract reduced statistically agitation time in 30, 60 and 120 min after injection compared to imipramine. Both aqueous and ethanol extract elevated immobility in minute 60(P<0.5). Conclusion: The present study suggested that Citrullus colocynthis extract could possess potential antidepressant and sedative effects which would be of therapeutic interest for using in the treatment of patients with depressive disorders. We suggest more research in this regard.
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瓜蒌果提取物对小鼠的抗抑郁作用
抑郁症具有多因素的特征,包括脑行为障碍、认知、精神运动和情绪过程的改变。全世界有数百万人患有这种疾病。这种疾病发生在所有年龄段的男性和女性中。本研究试图介绍一种传统药物与常见化学抗抑郁药物的比较。本实验旨在评价西葫芦果提取物的抗抑郁作用。材料与方法:雄性小鼠32只(Balb/c)随机分为4组,每组8只。动物适应和处理地西泮,丙咪嗪,水和水酒精提取物的甜瓜果。所有给药方式均为0.2ml/只腹腔注射。研磨后的植物原料用乙醇提取,减压蒸发。采用悬尾试验研究植物提取物对动物的抗抑郁作用。测试分别在注射前、注射后30分钟、60分钟和120分钟进行。结果:我们的数据显示,在注射后的所有时间内,腹腔注射水提物和乙醇提物后,静止时间比搅拌期都有统计学意义的增加(P<0.05)。与丙咪嗪相比,乙醇提取物在注射后30,60和120min的搅拌时间显著减少。水提液和乙醇提液均能提高60分钟内小鼠的不动性(P<0.5)。结论:芫荽提取物具有潜在的抗抑郁和镇静作用,可用于抑郁症患者的治疗。我们建议在这方面进行更多的研究。
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