Clinical and epidemiological significance of diarrhea in children with COVID-19

Q4 Medicine Infektsionnye Bolezni Pub Date : 2021-01-01 DOI:10.20953/1729-9225-2021-3-30-36

L. N. Mazankovа, S. G. Gorbunov, E. Samitova, I. Osmanov, V. Akimkin, A. Ploskireva, А.N. Os’kin, A. Mishkin

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Abstract

Objective. To show the clinical and epidemiological significance of diarrhea and SARS-CoV-2 excretion in the feces of COVID-19 patients in children. Patients and methods. 42 case histories of children with COVID-19 hospitalized and examined by PCR for SARS-CoV-2 RNA in nasal and oropharyngeal swabs, as well as in feces were ana-lyzed. Design: retrospective analysis of patient medical records. Results. It was shown that watery diarrhea was observed in 2.4% of children with verified COVID-19, vomiting and abdominal pain – in 4.8%. In the blood test, lymphocytosis prevailed. In all the examined patients, SARS-CoV-2 RNA was detected not only in nasal and oropharyngeal swabs, but also in feces, while in 4.8% of children, the virus was excreted in feces for a longer time than in the respiratory tract. In the epidemiological history of 100% of patients, there was no indication of contact with a patient with acute diarrhea. Conclusion. These facts indicate that, despite the infrequently registered diarrhea in COVID-19 in childhood, the detection of SARS-CoV-2 RNA in the feces of a significant number of such patients may have important clinical and epidemiological significance, contributing to the fecaloral transmission of this infection, which requires additional study due to the small number and incon-sistency of currently known data. Key words: diarrhea, COVID-19, SARS-CoV-2, children

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新冠肺炎患儿腹泻的临床和流行病学意义

目标。目的探讨儿童COVID-19患者腹泻及粪便中SARS-CoV-2排泄的临床及流行病学意义。患者和方法。对42例住院的COVID-19患儿进行鼻、口咽拭子及粪便中SARS-CoV-2 RNA PCR检测。设计:回顾性分析患者医疗记录。结果。结果显示，确诊COVID-19的儿童中有2.4%出现水样腹泻，4.8%出现呕吐和腹痛。血检以淋巴细胞增多为主。在所有检查的患者中，不仅在鼻咽拭子中检测到SARS-CoV-2 RNA，而且在粪便中也检测到SARS-CoV-2 RNA，而4.8%的儿童中，病毒在粪便中排泄的时间比在呼吸道中排泄的时间长。在100%患者的流行病学史中，没有与急性腹泻患者接触的指征。结论。这些事实表明，尽管COVID-19儿童腹泻病例并不多见，但在大量此类患者的粪便中检测到SARS-CoV-2 RNA可能具有重要的临床和流行病学意义，有助于这种感染的粪便传播，由于目前已知数据数量少且不一致，需要进一步研究。关键词:腹泻，COVID-19, SARS-CoV-2，儿童

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来源期刊

Infektsionnye Bolezni Medicine-Infectious Diseases

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.