A Stochastic Biofilm Disruption Model Based on Quorum Sensing Mimickers

IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Pub Date : 2023-07-05 DOI:10.1109/TMBMC.2023.3292321

Fatih Gulec;Andrew W. Eckford

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引用次数: 1

Abstract

Quorum sensing (QS) mimickers can be used as an effective tool to disrupt biofilms which consist of communicating bacteria and extracellular polymeric substances (EPS). In this paper, a stochastic biofilm disruption model based on the usage of QS mimickers is proposed. A chemical reaction network (CRN) involving four different states is employed to model the biological processes during the biofilm formation and its disruption via QS mimickers. In addition, a state-based stochastic simulation algorithm is proposed to simulate this CRN. The proposed model is validated by the in vitro experimental results of Pseudomonas aeruginosa biofilm and its disruption by rosmarinic acid as the QS mimicker. Our results show that there is an uncertainty in state transitions due to the effect of the randomness in the CRN. In addition to the QS activation threshold, the presented work demonstrates that there are underlying two more thresholds for the disruption of EPS and bacteria, which provides a realistic modeling for biofilm disruption with QS mimickers.

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基于群体感应模拟的随机生物膜破坏模型

群体感应（QS）模拟物可以作为一种有效的工具来破坏由通讯细菌和细胞外聚合物（EPS）组成的生物膜。本文提出了一种基于QS拟态器的随机生物膜破坏模型。采用涉及四种不同状态的化学反应网络（CRN），通过QS拟态器对生物膜形成及其破坏过程进行建模。此外，还提出了一种基于状态的随机模拟算法来模拟这种CRN。通过铜绿假单胞菌生物膜的体外实验结果以及迷迭香酸作为QS拟态物对其的破坏，验证了所提出的模型。我们的结果表明，由于CRN中随机性的影响，状态转换存在不确定性。除了QS激活阈值外，所提出的工作表明，EPS和细菌的破坏还有另外两个阈值，这为QS拟态物破坏生物膜提供了一个现实的模型。

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来源期刊

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Mathematics-Modeling and Simulation

CiteScore

3.90

自引率

13.60%

发文量

期刊介绍： As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.