Are Females More Sensitive to MDMA-Related Discriminative Stimuli?

J. Broadbear, B. Tunstall, Katherine Beringer
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引用次数: 1

Abstract

are examples of interoceptive cues which enable experienced users to distinguish the effects of MDMA from those of other drugs. Serotonin neurotransmission positively modulates the release of oxytocin into plasma [2]. To test the hypothesis that oxytocin receptor activation contributes to the interoceptive cues of MDMA in male and female rats, two peptidic oxytocin receptor ligands, the agonist carbetocin [3] and antagonist atosiban [4], were utilised in a 3-way drug discrimination paradigm [5].
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女性是否对mdma相关的歧视性刺激更敏感?
是内感受性线索的例子,它使有经验的使用者能够区分MDMA与其他药物的作用。血清素神经传递正向调节催产素释放到血浆[2]。为了验证催产素受体激活有助于雄性和雌性大鼠MDMA的内感受性线索的假设,我们将两种肽类催产素受体配体——激动剂卡贝霉素[3]和拮抗剂阿托西班[4]——用于3-way药物鉴别范式[5]。
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