Ansar Karimian, S. Farajnia, M. Ghojazadeh, F. Khaki-Khatibi
{"title":"The Association between PAI-1 Gene Promoter Polymorphism and Serum Serpin E1, MDA, and Hs-CRP Levels in Coronary Artery Disease","authors":"Ansar Karimian, S. Farajnia, M. Ghojazadeh, F. Khaki-Khatibi","doi":"10.17795/ICRJ-10(03)129","DOIUrl":null,"url":null,"abstract":"Background: Coronary artery disease (CAD) caused by atherosclerosis. Studies have shown that there are a number of factors which are closely related to the development and progression of CAD that include Cellular binding molecules like Plasminogen Activator Inhibitor-1(PAI-1), Lipid peroxidation, inflammation and hemostasis. Objectives: The present case-control study aimed to evaluate the association between Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G polymorphism and oxidative stress markers and Coronary Artery Disease (CAD). might be important in correlation with some other factors, such as increased or decreased triglyceride, cholesterol, and LDL and HDL levels. However, no significant correlation was observed between PAI-1 polymorphism","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"10 1","pages":"129-134"},"PeriodicalIF":0.2000,"publicationDate":"2016-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Cardiovascular Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17795/ICRJ-10(03)129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 3
Abstract
Background: Coronary artery disease (CAD) caused by atherosclerosis. Studies have shown that there are a number of factors which are closely related to the development and progression of CAD that include Cellular binding molecules like Plasminogen Activator Inhibitor-1(PAI-1), Lipid peroxidation, inflammation and hemostasis. Objectives: The present case-control study aimed to evaluate the association between Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G polymorphism and oxidative stress markers and Coronary Artery Disease (CAD). might be important in correlation with some other factors, such as increased or decreased triglyceride, cholesterol, and LDL and HDL levels. However, no significant correlation was observed between PAI-1 polymorphism
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