PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF THE ALKALOIDS OF MALVACEAE sensu lato SPECIES: A REVIEW

IF 0.5 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Quimica Nova Pub Date : 2023-06-26 DOI:10.21577/0100-4042.20230028

A. Sobreira, Janderson B.L. de Albuquerque, Wallace de Queiroz, P. de Souza, D. Fernandes, M. de Souza

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Abstract

Malvaceae sensu lato is a family containing about 245 genera and 4,465 species mainly distributed across tropical and subtropical regions worldwide. Species of this family usually contain alkaloids with anti-inflammatory, antinociceptive, antiparasitic, antimicrobial and anticancer properties due to its secondary metabolites. In this context, this review aims to checklist the alkaloids isolated from Malvaceae sensu lato species, evaluating their chemical profile and pharmacological potential, providing a broad and concise overview of these secondary metabolites. The results were collected from scientific databases such as Web of Science, Scifinder, Pubmed, ScienceDirect and Google Scholar, using the keywords “Alkaloids” and “Malvaceae”. Several pharmacological/ biological activities are reported in literature for the most varied alkaloid nuclei, such as: vasorelaxation of the mesentery of rats (cryptolepinone), antitrypanosomal activity (waltherione) and anti-inflammatory and bronchodilator activity (vasicine), which highlights a succession of activities related to this class of secondary metabolites. Presented data report the importance of the Malvaceae sensu lato family, demonstrating the biological relevance of its alkaloids, in order to contribute to scientific knowledge and the development of new drugs.

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锦葵生物碱的植物化学和药理研究进展

Malvaceae sensu lato是一个科，有245属4465种，主要分布在热带和亚热带地区。由于其次生代谢产物，本科植物通常含有具有抗炎、抗炎、抗寄生虫、抗菌和抗癌特性的生物碱。在此背景下，本综述旨在检查从Malvaceae sensu lato物种中分离的生物碱，评估其化学特征和药理潜力，为这些次生代谢产物提供一个广泛而简洁的概述。研究结果收集自Web of Science、Scifinder、Pubmed、ScienceDirect和b谷歌Scholar等科学数据库，检索关键词为“Alkaloids”和“Malvaceae”。文献报道了几种不同生物碱核的药理学/生物学活性，例如:大鼠肠系膜的血管松弛(隐肾上腺素)，抗锥虫活性(瓦西里酮)和抗炎和支气管扩张活性(瓦西里嗪)，这突出了与这类次级代谢物相关的一系列活性。提出的数据报告了Malvaceae sensu lato家族的重要性，展示了其生物碱的生物学相关性，以促进科学知识和新药的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quimica Nova 化学-化学综合

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

2-4 weeks

期刊介绍： Química Nova publishes in portuguese, spanish and english, original research articles, revisions, technical notes and articles about education in chemistry. All the manuscripts submitted to QN are evaluated by, at least, two reviewers (from Brazil and abroad) of recognized expertise in the field of chemistry involved in the manuscript. The Editorial Council can be eventually asked to review manuscripts. Editors are responsible for the final edition of QN.