Efficiency of leptin gene polymorphisms in the evaluation of the growth performance and carcass measurements of v-line and Baladi black rabbits

4区农林科学 Q3 Agricultural and Biological Sciences Genetika-Belgrade Pub Date : 2023-01-01 DOI:10.2298/gensr2301319r

H. Radwan, A. Ateya, El-HithamAmr Abo, Shimaa A. Sakr, M. Fouda, R. Darwish, A. El-Desoky

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Abstract

This study investigated the association between both polymorphisms and metabolic marker changes of the leptin gene, and body weight, weight gain, carcass traits, feed intake, and feed conversion ratio. Blood samples were collected from 60 V-line and 60 Baladi Black rabbits for DNA extraction and biochemical analysis. DNA sequencing of leptin (202-bp) revealed four non-synonymous single nucleotide polymorphism (SNPs) that characterized a number of V-line rabbits. Statistical analysis revealed that the identified SNPs were associated with rabbit growth and carcass measurements (p < 0.05). A discriminant analysis model showed a high classification percentage for the identified SNPs within and between breeds using body weight at 5-14 weeks of age (91.7%), slaughter traits (91.6%), feed intake, daily feed intake, and feed conversion ratio (76.7%). This study reveals that leptin gene could be a candidate for growth traits in rabbits enabling the development of marker-assisted selection (MAS) in different rabbit breeds.

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瘦素基因多态性在评价v系和巴拉迪黑兔生长性能和胴体测量中的有效性

本研究旨在探讨瘦素基因多态性和代谢标志物变化与体重、增重、胴体性状、采食量和饲料系数的关系。采集v系黑兔和巴拉地黑兔各60只，进行DNA提取和生化分析。瘦素(leptin)的DNA测序(202-bp)显示了4个非同义单核苷酸多态性(SNPs)，这些多态性具有许多v系兔的特征。统计分析表明，所鉴定的snp与家兔生长和胴体尺寸相关(p < 0.05)。判别分析模型显示，5 ~ 14周龄体重(91.7%)、屠宰性状(91.6%)、采食量、日采食量和饲料系数(76.7%)对品种内和品种间snp的分类率较高。该研究表明，瘦素基因可能是家兔生长性状的候选基因，从而使不同家兔品种的标记辅助选择(MAS)得以发展。

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来源期刊

Genetika-Belgrade AGRONOMY-GENETICS & HEREDITY

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The GENETIKA is dedicated to genetic studies of all organisms including genetics of microorganisms, plant genetics, animal genetics, human genetics, molecular genetics, genomics, functional genomics, plant and animal breeding, population and evolutionary genetics, mutagenesis and genotoxicology and biotechnology.