MECHANISMS OF INFLUENCE OF UNBALANCED FEEDING ON MORPHO-FUNCTIONAL STATE OF LIVER IN PREGNANT RATS

Periodyk Naukowy Akademii Polonijnej Pub Date : 2021-01-01 DOI:10.23856/4532

M. Kuznetsova, I. Kuznetsova

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Abstract

Summary Pathology of the organs of the hepatobiliary system is one of the leading causes of death in highly developed countries. Among various factors that can negatively affect the morphofunctional state of the liver in the mother-fetus system, the alimentary factor occupies the first place. The aim of this study was to establish the mechanisms of influence of excess nutrients in the diet on the morphology and functional state of the liver of pregnant rats. The structural and functional state of the liver of 7 rats that received an excess diet during pregnancy and 6 rats of the control group were studied. Morphological changes were manifested by uneven expression of eNOS and a positive reaction of iNOS, which was observed not only in macrophages, but also in single endothe-liocytes of dilated sinusoids. Functional changes were characterized by the development of dyslipidemia in the blood serum and the accumulation of TG and NEFA in the liver tissues. The data obtained in the course of the study may indicate pronounced disorders of lipid metabolism, which can be regarded as a risk factor for the development of steatosis, liver fibrosis, atherosclerosis and type 2 diabetes mellitus.

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不平衡摄食对妊娠大鼠肝脏形态功能状态的影响机制

在高度发达的国家，肝胆系统器官的病理是导致死亡的主要原因之一。在对母胎系统中肝脏形态功能状态产生负面影响的各种因素中，饮食因素占据首位。本研究旨在探讨饲粮中过量营养物质对妊娠大鼠肝脏形态和功能的影响机制。研究了妊娠期过量饮食组7只大鼠和对照组6只大鼠肝脏的结构和功能状况。形态学变化表现为eNOS的不均匀表达和iNOS的阳性反应，不仅在巨噬细胞中可见，在扩张的窦状窦的单个内皮细胞中也可见。功能变化的特征是血清中出现血脂异常，肝组织中TG和NEFA的积累。在研究过程中获得的数据可能表明明显的脂质代谢紊乱，这可能是脂肪变性、肝纤维化、动脉粥样硬化和2型糖尿病发生的危险因素。

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