Study of Karyotyping and the Genotoxic Effects of Taxol Drug on the Somatic Bone Marrow Cells of Albino Wister Rats

Abstract

In this study, the chromosome 2N was calculated for the somatic cells of the male albino (Albino Wister Rats) obtained from the Animal House at the Faculty of Science, Misurata University. The study also identified some chromosomal stages, such as the metaphase. The results indicated that the chromosome number 2N=42, in addition to measuring the total and relative length of the chromosomes, and then arrange the chromosomes descending on their lengths. The chromosomal abnormalities resulting from colchicine exposure (such as the scattered metaphase, the ring chromosome, the chromatid separation and the chromosomal break) were also shown, while the chromosomal abnormalities caused by the taxol treatment were: agglomerated colchicine metaphase, associated chromosomal endings, chromosomal viscosity, multiple chromosomal group and lack of chromosomal group).