Study of Co-Relation between Hepatitis C Viral Load with Clinical Presentations, Laboratory Investigations and Sofosbuvir Combination Therapy

Abstract

Hepatitis C virus is a causative agent of both acute and chronic liver disease and is associated with varied clinical presentations. Aims & Objectives: The study was undertaken co-relate the various clinical manifestations and derangement of liver and endocrine function with HCV viral replication and to find out the impact of Sofosbuvir combination therapy. Result: Derangement of liver function as indicated by Bilirubin, AST and ALT has significant corelation with active viral replication as indicated by viral load assay. Derangement of Thyroid function is also found in a third of HCV infected patients. The study also found Sofosbuvir combination therapy induces an early virologic response in both Genotype 1 and Genotype 3 infection.