{"title":"Beta-Lactamases and ESBL","authors":"A. A","doi":"10.23880/vij-16000225","DOIUrl":null,"url":null,"abstract":"Microbial resistance through extended-spectrum β-lactamase (ESBL) was first reported in the early 1980s in Europe and subsequently in the United States soon after the introduction of third-generation cephalosporins in clinical practice. β -Lactamases are enzymes that inactivate β -lactam antibiotics by opening the β-lactam ring of penicillins and cephalosporin and abolish their antimicrobial activity. Beta-lactamases have been described for many species of grampositive and gram-negative bacteria. Some β-lactamases are plasmid mediated while others are chromosomally","PeriodicalId":93395,"journal":{"name":"Virology & immunology journal","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology & immunology journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23880/vij-16000225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Microbial resistance through extended-spectrum β-lactamase (ESBL) was first reported in the early 1980s in Europe and subsequently in the United States soon after the introduction of third-generation cephalosporins in clinical practice. β -Lactamases are enzymes that inactivate β -lactam antibiotics by opening the β-lactam ring of penicillins and cephalosporin and abolish their antimicrobial activity. Beta-lactamases have been described for many species of grampositive and gram-negative bacteria. Some β-lactamases are plasmid mediated while others are chromosomally
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