Expression of Cancer-testis Antigens in Adenoid Cystic Carcinoma of the Salivary Glands Correlates with Clinical Outcomes

IF 0.3 4区 医学 Q4 ENGINEERING, BIOMEDICAL Journal of Hard Tissue Biology Pub Date : 2021-01-01 DOI:10.2485/jhtb.30.283
Su-Xia Liang, H. Fang, Wei Chen, Yingbin Yan
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Abstract

This study aimed to explore the expression and clinicopathological significance of CTAs MAGE-1, NY-ESO-1, MAGE-C2 and SCP-1 in adenoid cystic carcinoma (ACC). Immunohistochemistry was used to detect their expressions in 70 cases of ACC, and in 6 healthy tumor-adjacent salivary glands. The correlation between the expressions of the four CTAs, clinical and pathological features, and patients’ overall survival (OS) were analyzed. Of the 70 ACC cases, strong staining was observed in 43 (61.4%) for MAGE-1, 14 (20%) for NY-ESO-1, 9 (12.9%) for SCP-1, and 6 (8.6%) for MAGE-C2. We also found some significant correlations between the CTAs expression and clinicopathological parameters, for example, MAGE-1 and tumor size, NY-ESO-1 and distant metastasis, MAGE-C2 and tumor site, SCP-1 and age, SCP-1 and histopathological types (P < 0.05). Patients with any single CTAs positive staining showed a similar OS compared to those with negative staining, however patients with strong expression (score 6-7) of MAGE-C2 showed a significantly reduced OS compared to those scored 0-5 (P < 0.05). There was no OS difference between patients expressing simultaneously any 2 of the 4 CTAs and those with negative expression or those expressing only one of the 2 CTAs. Similar results were found in patients expressing at least 3 CTAs compared with patients expressing less than 3 CTAs. However, patients with the four CTAs co-expression had a substantially reduced mean survival time of 131.8 months compared with 176.5 months in patients with at least one CTA negative (P < 0.05). In conclusion, a significant fraction of patients with ACC showed expression of MAGE-1, NY-ESO-1, MAGE-C2 and SCP-1, indicating these CTAs might represent potential antigens for cancer vaccines. In addition, MAGE-C2 may be an important prognostic marker of ACC.
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唾液腺腺样囊性癌中癌睾丸抗原的表达与临床预后的关系
本研究旨在探讨cta MAGE-1、NY-ESO-1、MAGE-C2和SCP-1在腺样囊性癌(adenoid cystic carcinoma, ACC)中的表达及其临床病理意义。应用免疫组织化学方法检测70例ACC患者及6例健康肿瘤邻近唾液腺的表达。分析4种cta的表达与临床病理特征、患者总生存期(OS)的相关性。在70例ACC病例中,有43例(61.4%)为MAGE-1, 14例(20%)为NY-ESO-1, 9例(12.9%)为SCP-1, 6例(8.6%)为MAGE-C2。我们还发现cta的表达与MAGE-1与肿瘤大小、NY-ESO-1与远处转移、MAGE-C2与肿瘤部位、SCP-1与年龄、SCP-1与组织病理类型等临床病理参数均有显著相关性(P < 0.05)。任何单一cta阳性染色患者的OS与阴性染色患者相似,但MAGE-C2强表达患者(评分6-7)的OS与评分0-5的患者相比显着降低(P < 0.05)。同时表达4种cta中的任何2种的患者与阴性表达或仅表达2种cta中的一种的患者之间没有OS差异。与表达少于3个cta的患者相比,表达至少3个cta的患者也发现了类似的结果。然而,四种CTA共表达患者的平均生存时间明显缩短,为131.8个月,而至少有一种CTA阴性患者的平均生存时间为176.5个月(P < 0.05)。综上所述,相当一部分ACC患者表达MAGE-1、NY-ESO-1、MAGE-C2和SCP-1,表明这些cta可能是癌症疫苗的潜在抗原。此外,MAGE-C2可能是ACC的重要预后指标。
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来源期刊
Journal of Hard Tissue Biology
Journal of Hard Tissue Biology ENGINEERING, BIOMEDICAL-
CiteScore
0.90
自引率
0.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Information not localized
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