Cytokeratin 8 Promoted Sinonasal Inverted Papilloma Malignant Transformation to SNSCC

Abstract

: The sinonasal inverted papilloma is one of the more common benign tumors of the nasal cavity and sinus. It origi-nates from the schneiderian membrane. It has the characteristics of easy recurrence and malignant transformation. This experiment found that Cytokeratin 8 expression increased in the sinonasal inverted papilloma. To better detect the role of Cytokeratin 8 in the proliferation and deterioration of the sinonasal inverted papilloma, we divided the sinonasal inverted papilloma into NIPN, NIPAP, and NIPAH by histological. The expression of Cytokeratin 8 in the sinonasal inverted papilloma was detected by immunohistochemistry. We found that the increased expression of Cytokeratin 8 was consistent with the invasion of sinonasal squamous cell carcinoma. In vitro , it was found that after Cytokeratin 8 interference, the proliferative and invasion of head and neck squamous cells were decreased. Cytokeratin 8 played an important role of sinonasal inverted papilloma malignant transformation to sinonasal squamous cell carcinoma. Inhibition of Cytokeratin 8 could diminish the proliferation and block the invasion of head and neck squamous cells.