Intestinal barrier disorders and metabolic endotoxemia in obesity: Current knowledge

IF 0.2 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Postȩpy higieny i medycyny doświadczalnej Pub Date : 2022-01-01 DOI:10.2478/ahem-2022-0008
M. Potrykus, M. Szymański, Ł. Kaska, A. Janczy
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引用次数: 1

Abstract

Abstract The World Health Organization reports that the prevalent problem of excessive weight and obesity currently affects about 1.9 billion people worldwide and is the fifth most common death factor among patients. In view of the growing number of patients with obesity, attention is drawn to the insufficient effectiveness of behavioral treatment methods. In addition to genetic and environmental factors leading to the consumption of excess energy in the diet and the accumulation of adipose tissue, attention is paid to the role of intestinal microbiota in maintaining a normal body weight. Dysbiosis – a disorder in the composition of the gut microbiota – is mentioned as one of the contributing factors to the development of metabolic diseases, including obesity, type 2 diabetes, and cardiovascular disorders. The human gastrointestinal tract is colonized largely by a group of Gram-negative bacteria that are indicated to be a source of lipopolysaccharide (LPS), associated with inducing systemic inflammation and endotoxemia. Research suggests that disturbances in the gut microbiota, leading to damage to the intestinal barrier and an increase in circulating LPS, are implicated in obesity and other metabolic disorders. Plasma LPS and lipopolysaccharide-binding protein (LBP) levels have been shown to be elevated in individuals with excess body weight. Bariatric surgery has become a popular treatment option, leading to stable weight loss and an improvement in obesity-related conditions. The aim of this study was to characterize the factors that promote the induction of metabolic endotoxemia and its associated health consequences, along with the presentation of their changes after bariatric surgery.
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肥胖症的肠屏障障碍和代谢性内毒素血症:目前的知识
世界卫生组织报告称,超重和肥胖的普遍问题目前影响着全世界约19亿人,是患者中第五大最常见的死亡因素。鉴于肥胖患者数量的不断增加,人们开始注意到行为治疗方法的有效性不足。除了遗传和环境因素导致饮食中过量能量的消耗和脂肪组织的积累外,肠道微生物群在维持正常体重方面的作用也受到关注。生态失调——一种肠道微生物群组成紊乱——被认为是代谢性疾病发展的因素之一,包括肥胖、2型糖尿病和心血管疾病。人类胃肠道主要由一组革兰氏阴性细菌定植,这些细菌被认为是脂多糖(LPS)的来源,与诱导全身炎症和内毒素血症有关。研究表明,肠道微生物群紊乱,导致肠道屏障受损和循环LPS增加,与肥胖和其他代谢紊乱有关。血浆LPS和脂多糖结合蛋白(LBP)水平已被证明在体重超标的个体中升高。减肥手术已经成为一种流行的治疗选择,导致稳定的体重减轻和肥胖相关疾病的改善。本研究的目的是描述促进代谢内毒素血症的诱发因素及其相关的健康后果,以及减肥手术后这些因素的变化。
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来源期刊
Postȩpy higieny i medycyny doświadczalnej
Postȩpy higieny i medycyny doświadczalnej MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.60
自引率
0.00%
发文量
50
审稿时长
4-8 weeks
期刊介绍: Advances in Hygiene and Experimental Medicine (PHMD) is a scientific journal affiliated with the Institute of Immunology and Experimental Therapy by the Polish Academy of Sciences in Wrocław. The journal publishes articles from the field of experimental medicine and related sciences, with particular emphasis on immunology, oncology, cell biology, microbiology, and genetics. The journal publishes review and original works both in Polish and English. All journal publications are available via the Open Access formula in line with the principles of the Creative Commons licence.
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