Correlation between brush cytology results and histopathological examination in diagnostic evaluation of precancerous conditions and laryngeal cancer: A prospective study

Abstract

Abstract Introduction The aim of the paper was to demonstrate that brush cytology can be useful in diagnostic evaluation of precancerous states and laryngeal cancer. Materials and Methods Ninety-two patients were analyzed. The control group included patients with benign laryngeal lesions, while the study group was composed of patients in whom a precancerous condition or laryngeal cancer was suspected. Material for histopathological and cytological examination was collected during a laryngeal microsurgery. The authors analyzed the consistency of the results of cytological and histopathological examination in the diagnostic evaluation of precancerous conditions and laryngeal cancer. Results Comparing diagnoses based on cytological examination with the results of histopathological examinations, the authors observed that there was a strong and statistically significant (p<0.001) correlation between the results. The accuracy of brush cytology in the conducted study indicates that the sensitivity and specificity of the test reaches 90.09% and 93.5% with 4 false negative and 3 false positive results. Positive prediction reached 93% and negative prediction reached 91.5%. Conclusions Brush cytology of the larynx may be useful in screening and as an auxiliary test in diagnostic evaluation of precancerous conditions and laryngeal cancer.