Covid-19 Infection in Patients with Crohn's Disease on Intensified Adalimumab Treatment with Gastrointestinal Symptoms

Kiarash Pour Modjib, Christian G Sebesta, Christian Sebesta
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Abstract

Itself, that causes severe lung damage. Thus, it was hypothesized that the use of anti TNFα antibodies could be beneficial in SARS-CoV-2 infection [1]. TNFα has various biological effects such as amplification of proinflammatory and chemotactic mediators, migration of neutrophils and up-regulation of adhesion molecules. Therefore, besides direct cytopathic effect of SARSCoV-2, suppressing of host inflammatory response could serve as another treatment option [2].
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阿达木单抗强化治疗伴胃肠道症状的克罗恩病患者Covid-19感染
这本身就会导致严重的肺损伤。因此,我们推测抗TNFα抗体的使用可能对SARS-CoV-2感染有益。TNFα具有多种生物学效应,如扩增促炎和趋化介质、中性粒细胞迁移和上调粘附分子。因此,除了SARSCoV-2的直接细胞病变作用外,抑制宿主炎症反应可能是另一种治疗选择[2]。
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