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An Unusual Skin Adverse Event after Switching from Intravenous to Subcutaneous VEDOLIZUMAB Therapy in Patients with Ulcerative Colitis 溃疡性结肠炎患者从静脉注射转为皮下VEDOLIZUMAB治疗后不寻常的皮肤不良事件
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550576
Anne-Sophie Peaucelle, C. Gay, M. Lefèvre, M. Barrau, G. Boschetti, S. Nancey, X. Roblin
. Soon, she complained about occurrence of
. 不久,她抱怨了发生的事
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引用次数: 0
Case Report of Modified Sauvé-Kapandji Technique Using Endobutton Suture in Secondary Treatment of Madelung Deformity 改良sauv<s:1> - kapandji技术应用内扣缝合二次治疗马德隆畸形1例报告
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550587
Ghassan Zakhia-Douaihy, Yehia Tfayli, Ahmad Salaheddine Naja, M. Issa, Jean Paul Rizk
The Sauvé-Kapandji technique is considered a useful treatment option for distal radioulnar joint instability encountered in many conditions, such as Madelung deformity or in post-traumatic entities. However, post-operative instability of the proximal ulnar stump and radioulnar convergence may be symptomatic and is still a major concern. Despite proximal ulnar stump stabilization with various techniques, many patients still complain of pain and limitation of wrist movement. We report a case of a patient with Madelung disease treated initially by corrective radial and ulnar osteotomy, and then encountered a post-traumatic distal radioulnar joint instability. This condition was treated with a modified Sauvé-Kapandji procedure using a single endobutton suture, leading to good clinical and radiological results.
sauv - kapandji技术被认为是在许多情况下(如马德隆畸形或创伤后个体)遇到的远端尺桡关节不稳定的有效治疗选择。然而,术后尺近端残端不稳定和尺桡收敛可能是有症状的,仍然是一个主要的问题。尽管使用各种技术稳定近端尺端残端,许多患者仍然抱怨疼痛和手腕活动受限。我们报告了一例马德隆病患者,最初通过矫正桡骨和尺骨截骨治疗,然后遇到创伤后远端尺桡关节不稳定。采用改良的sauv - kapandji手术,采用单内扣缝合,取得了良好的临床和放射学结果。
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引用次数: 0
Nivolumab PD-1 Blockade as Bridge to Allogeneic Stem Cell Transplant (HSCT) in Gray-Zone Lymphoma: Case Report 纳武单抗PD-1阻断作为灰色地带淋巴瘤同种异体干细胞移植(HSCT)的桥梁:病例报告
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550614
M. Nicolosi, Chiara Maria Dellacasa, M. Novo, A. Busca, R. Freilone, B. Botto
Received: April 17, 2023 Accepted: May 25, 2023 Published: June 21, 2023 Abstract Mediastinal Gray-zone lymphoma (GZL) is a rare entity of lymphoma, with a typical overlapping in terms of biologic and morphologic features between classic Hodgkin lymphoma (cHL) and primary mediastinal large B-cell lymphoma (PMBCL). The therapeutic approaches for these patients remain controversial, and most standard approaches include a combination of chemotherapy, immunotherapy, and, recently, radiation. Unfortunately, overall survival (OS) and progression free survival (PFS) remain dreary. This case report will discuss an adult patient with mediastinal GZL treated as first line with chemotherapy approaches; after an initial lack of response, we decided for a strategy with the anti PD-1 blockade Nivolumab as bridge to the allogeneic hematopoietic stem cell transplant (HSCT). The patient obtained a complete response before the HSCT maintaining this result after the HSCT with temporary grade I and II GVHD, suggesting the important role of the checkpoint inhibitor in this setting of patients. Clinical trials, with larger groups of patients, and longer follow-up are needed to better define safety and prognostic impact of anti PD1 and subsequent allogeneic HCT for the treatment of GZL.
摘要纵隔灰色区淋巴瘤(GZL)是一种罕见的淋巴瘤,在生物学和形态学上与经典霍奇金淋巴瘤(cHL)和原发性纵隔大b细胞淋巴瘤(PMBCL)具有典型的重叠。这些患者的治疗方法仍然存在争议,大多数标准方法包括化疗、免疫治疗和最近的放射治疗的组合。不幸的是,总生存期(OS)和无进展生存期(PFS)仍然令人沮丧。本病例报告将讨论一个成人纵隔GZL患者作为一线化疗方法;在最初缺乏反应后,我们决定采用抗PD-1阻断剂Nivolumab作为异基因造血干细胞移植(HSCT)的桥梁。患者在接受HSCT治疗前获得完全缓解,在接受临时性I级和II级GVHD的HSCT治疗后保持了这一结果,这表明检查点抑制剂在这类患者中的重要作用。为了更好地确定抗PD1和随后的同种异体HCT治疗GZL的安全性和预后影响,需要更大的患者群体和更长的随访时间的临床试验。
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引用次数: 0
Human Herpesvirus 6 Reactivation: A Rare Case of Acute Liver Failure and Literature Review 人类疱疹病毒6型再激活:一例罕见的急性肝衰竭并文献复习
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550564
H. Wozniak, Jeanne-Laure Vionnet, M. Schibler, Claudia Paula Heidegger, J. Pugin, L. Spahr, S. Cereghetti
,
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引用次数: 0
Huaier Effects on Prevention and Inhibition of Spontaneous SARS-CoV-2 Virion Production by Repeated Pfizer-BioNTech mRNA Vaccination 重复接种Pfizer-BioNTech mRNA预防和抑制自发性SARS-CoV-2病毒粒子产生的淮儿效应
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550568
Manami Tanaka, Tomoo Tanaka, Fei Teng, Xiaolong Zhu, Hong Lin, Zhu-Quan Luo, S. Sadahiro, Toshiyuki Suzuki, Y. Maeda, Ding Wei, Zheng Lu
,
,
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引用次数: 0
Piezosurgery Removal of Mandibular Tori: A Case Series 下颌骨环体的压电手术去除:一个案例系列
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550615
Pozzetti E, Garibaldi J, Cassinotto E, Figliomeno E, Merlini A
,
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引用次数: 0
Artificial Intelligence for Smart Procedural Sedation in the Gastrointestinal Endoscopy Suite 人工智能在胃肠道内窥镜套件中的应用
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550624
C. Zeeni, C. Karam, Nancy Abou Nafeh, M. Aouad, R. Kaddoum, S. Siddik-Sayyid, Amro Khalili
Artificial intelligence (AI) is defined as the science of creating intelligent machines. AI has grown exponentially, and its systems have made their way into the anesthesia field. The purpose of this review is to explore how the practice of anesthesiology in the gastrointestinal (GI) endoscopy suite changed with AI. Current AI anesthesia systems in the endoscopy suite include open and closed loop anesthesia delivery systems. The most widely used open loop system is the target-controlled infusion (TCI). During TCI, a drug is given automatically using a pump controlled by a computer. The aim is to achieve a chosen target plasma concentration, based on the hypothesis that the pharmacological effect is proportional to the drug’s plasma concentration. Closed loop systems regulate the drug’s dosage by checking a controlling parameter such as the patient himself in patient-maintained sedation, or the bispectral index in computer-assisted personalized sedation. As such, the closed loop system regulates the dose according to continuous feedback from the patient. Recent innovations in AI include machine learning and deep learning models that may have future applications in the endoscopy suite. Machine learning models look for patterns in vast amounts of data to draw conclusions. Deep learning models gain the ability to learn new information that they were not “explicitly programmed” to learn and make changes to their function based on that new information. Although the future of AI in anesthesia and the GI endoscopy suite seems bright, one must always keep in mind its shortcomings.
人工智能(AI)被定义为创造智能机器的科学。人工智能呈指数级增长,其系统已经进入麻醉领域。本综述的目的是探讨人工智能如何改变胃肠道(GI)内窥镜组的麻醉实践。目前内窥镜套件中的人工智能麻醉系统包括开放和闭环麻醉输送系统。目前应用最广泛的开环系统是靶控输注(TCI)。在TCI过程中,通过计算机控制的泵自动给药。其目的是根据药物的药理作用与药物的血浆浓度成正比的假设,达到选定的目标血浆浓度。闭环系统通过检查一个控制参数来调节药物的剂量,比如病人自己在病人维持的镇静中,或者电脑辅助的个性化镇静中的双谱指数。因此,闭环系统根据患者的连续反馈来调节剂量。人工智能的最新创新包括机器学习和深度学习模型,这些模型可能在内窥镜套件中有未来的应用。机器学习模型在大量数据中寻找模式以得出结论。深度学习模型获得了学习新信息的能力,这些信息不是“明确编程”来学习的,并根据新信息对其功能进行更改。尽管人工智能在麻醉和胃肠道内窥镜套件方面的前景似乎很光明,但我们必须始终牢记它的缺点。
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引用次数: 0
Ovarian Dysgerminoma - Challenging Presurgical Diagnosis and Mini-Mally Invasive Treatment. 卵巢异常生殖细胞瘤-具有挑战性的术前诊断和微创治疗。
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550573
K Otto, O Ebertz, C Matsingou, D Andrikos, R L De Wilde, H Krentel

Dysgerminoma is a rare malignant germ cell tumor of the ovary that often affects women in reproductive age. The presurgical differentiation of dysgerminoma from benign conditions is challenging. In early stages, malignant dysgerminoma can be treated with fertility sparing surgery. We present a pictorial non-systematic review of literature, discuss diagnostic challenges in ultrasound and radiological imaging and present laparoscopic treatment options in a young woman with dysgerminoma.

异常生殖细胞瘤是一种罕见的卵巢恶性生殖细胞瘤,常发生于育龄妇女。手术前对良性生殖细胞异常瘤的鉴别是具有挑战性的。在早期阶段,恶性生殖异常瘤可以用保留生育能力的手术治疗。我们提出了一个图像的非系统的文献回顾,讨论在超声和放射成像诊断挑战,并提出了腹腔镜治疗方案的年轻女性生殖细胞异常瘤。
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引用次数: 0
Pulmonary Vein Stenosis in an Infant with Bronchopulmonary Dysplasia and Partial Anomalous Pulmonary Venous Circulation: Is This Double Trouble? 支气管肺发育不良和部分肺静脉循环异常的婴儿肺静脉狭窄:这是双重麻烦吗?
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550599
R. Lalitha, K. Norozi, S. Bhattacharya
Pulmonary vein stenosis (PVS) in preterm infants is a rare emerging complication that is associated with bronchopulmonary dysplasia (BPD) which has an unpredictable outcome. Though PVS can be associated with congenital heart defects, its concurrent occurrence in a preterm infant with partial anomalous pulmonary venous return (PAPVR) and severe BPD has not been documented yet. This case shows the potential progressive nature of PVS that might have been aggravated by the presence of two disease condition associated with it and the need for heighted vigilance when an unusual clinical trajectory is demonstrated in a high-risk preterm infant.
早产儿肺静脉狭窄(PVS)是一种罕见的与支气管肺发育不良(BPD)相关的并发症,其预后难以预测。虽然PVS可能与先天性心脏缺陷有关,但其同时发生在部分肺静脉回流异常(PAPVR)和严重BPD的早产儿中尚未见文献记载。本病例显示了PVS的潜在进行性,可能因两种相关疾病的存在而加重,当高危早产儿出现不寻常的临床轨迹时,需要高度警惕。
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引用次数: 0
A Case of Post-Myocardial Infarction Ventricular Septal Rupture and Intramyocardial Dissection 心肌梗死后室间隔破裂并发心内夹层1例
Pub Date : 2023-01-01 DOI: 10.26502/acmcr.96550605
Jessica Y C Huang, Michael Bourne, B. Rosenfeld, Federico E. Mordini, Christian D. Nagy, Andrew Chen
Ventricular septal rupture (VSR), albeit rare, is a deadly consequence of ST elevation myocardial infarction (STEMI). Our patient described here presented with both post-infarction VSR and intramyocardial dissection (IMD) of the right ventricle (RV), a subtype of left ventricular free wall rupture (LVFWR). This case highlights the importance of prompt diagnosis of these post-myocardial infarction (MI) complications and the current limitations of surgical and percutaneous repair.
室间隔破裂(VSR)虽然罕见,但却是ST段抬高型心肌梗死(STEMI)的致命后果。本例患者表现为梗死后VSR和右心室(RV)心肌内剥离(IMD),这是左心室游离壁破裂(LVFWR)的一种亚型。这个病例强调了及时诊断这些心肌梗死后(MI)并发症的重要性,以及目前手术和经皮修复的局限性。
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Archives of clinical and medical case reports
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