IN VITRO ANTI-PROLIFERATIVE ACTIVITY OF NOVEL ANALOGUES OF(E)-2-BENZYLIDENE-N-(3-(3-OXO-2,3- DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)PROPYL) HYDRAZINE-1-CARBOTHIOAMIDE
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Abstract
A novel analog of substituted-(E)-2-benzylidene-N-(3-(3-oxo-2,3-dihydro-4H-benzo[b] [1,4] oxazin-4-yl)propyl) hydrazine-1-carbothioamides (9a-j) appeared to be assess being anti-proliferative activity in vitro environment some of the newly derived derivatives have shown sufficiently great to modest suppression in the number of cells in cancer among GrowthInhibition50 was (0.180-4.20 µM). Compounds 9a, 9b, 9d, 9g, 9i, and 9j showed promising acts contrarily 4 human being tumor cell lines. Out of 9a and 9g displayed heartening cancer act in opposition to IMR-32 (Human being neuroblastoma cells) at 0.23 M and MIAPACA(human pancreatic carcinoma cells) at 0.18 M respectively. Notably, compound 9g showed significant activity at 0.18 M against the MIAPACA cell line respectively.
期刊介绍：
RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.
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