Relationship between Thickness of Early Oral Tongue Carcinoma (T1, T2) with Cervical Lymph Node Metastasis

IF 0.1 Q4 OTORHINOLARYNGOLOGY Bangladesh Journal of Otorhinolaryngology Pub Date : 2021-04-28 DOI:10.3329/BJO.V27I1.53202
A. Razzak, B. H. Siddique, Azharul Islam, H. Haque, A. Sattar, Sayed Farhan Ali Razib, Effat Zahan Abdullah, A. M. Jewel, Jaber Al Sayied, Quamruzzaman
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Abstract

Background: Carcinoma of oral tongue is the most common oral cancer and because of its structure and function is prone for early local and regional spread of cancer. The final outcome of a primary tongue carcinoma patient depends upon various prognostic factors like thickness of tumor, depth of invasion, size of lesion and neck node 67metastasis. Risk of metastasis and spread to neck nodes increases with increase in tumor thickness Methods: This prospective observational study was carried out in the Department of OtolayngologyHead & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka for 18 months. Thirty patients with early oral tongue carcinoma i.e.T1 & T 2 as per UICC and AJC criteria were included in this study by purposive non-randomized sampling technique. Result of the study were expressed as mean, standard deviation (+SD), frequency and percentages. Unpaired Student’s t-test and Pearson’s correlation co-efficient (r) test were performed. Results: Result of the study showed the mean (+SD) thickness of the tumor was 3.62 (+1.46) mm. Minimum thickness 1.1mm and maximum thickness 7.8mm. Only 21 (70%) subjects neck node were metastasized from tongue and mean (+SD) tumor thickness of the positive neck node metastasis was 5.54 (+1.07) mm and negative neck node metastasis was 2.87 (+0.75) mm. This indicated a significant difference between the groups. Pearson’s correlation co-efficient r (+0.981) which indicated tumor thickness was positively correlated with neck node metastasis. Conclusion: Tumor thickness of the early oral carcinoma positively correlated with neck node metastasis. Correlation between thickness and metastatic lymph node can help planning the treatment regimen and indicate the disease prognosis.
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早期舌癌T1、T2厚度与颈淋巴结转移的关系
背景:口腔舌癌是最常见的口腔癌,因其结构和功能特点,易发生早期局部和区域扩散。原发性舌癌患者的最终预后取决于多种预后因素,如肿瘤厚度、浸润深度、病变大小和颈结转移。方法:本前瞻性观察研究在达卡Bangabandhu Sheikh Mujib医科大学(BSMMU)耳鼻喉头颈外科进行,为期18个月。本研究采用有目的的非随机抽样方法,纳入30例符合UICC和AJC标准的早期舌癌患者,即t1和t2。研究结果以均数、标准差(+SD)、频次和百分比表示。进行Unpaired Student t检验和Pearson相关系数(r)检验。结果:肿瘤平均(+SD)厚度为3.62 (+1.46)mm,最小厚度1.1mm,最大厚度7.8mm。仅21例(70%)患者颈结舌部转移,阳性颈结转移瘤的平均(+SD)厚度为5.54 (+1.07)mm,阴性颈结转移瘤的平均(+SD)厚度为2.87 (+0.75)mm,组间差异有统计学意义。Pearson相关系数r(+0.981)表明肿瘤厚度与颈结转移呈正相关。结论:早期口腔癌的肿瘤厚度与颈结转移呈正相关。厚度与转移性淋巴结的相关性有助于制定治疗方案并提示疾病预后。
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