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A Comparative Study of Fiberoptic Laryngoscopy (FOL) and Indirect Laryngoscopy in the Diagnosis of Patients with Vocal Cord Lesions 纤维喉镜与间接喉镜在声带病变诊断中的比较研究
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68129
Mohammad Nazrul Islam, Dipankar Lodh, Md Shahriar Islam, Md Arifuzzaman, Bashudev Kumar Saha, Md Shah Alam
Background: Change of voice is one of the common complaints in ENT practice and hoarseness of voice is the commonest symptom of changed voice quality. Hoarseness is invariably the earliest manifestation of conditions directly or indirectly affecting the voice apparatus. Though most common causes of hoarseness are benign and vocal abuse is the commonest among them, but we should always investigate for more sinister pathology like malignancy. The aim of this study was to compare the diagnostic yields of fibreoptic laryngoscopy (FOL) with that of indirect laryngoscopy in the diagnosis of vocal cord lesions. Objectives: To compare fibreoptic laryngoscopy (FOL) and indirect laryngoscopy in the diagnosis of vocal cord lesions as the cause of voice change. Methods: This is a cross-sectional study which has been conducted in the Department of ENT and Head Neck Surgery, SSMC Mitford Hospital with a sample size of 87 cases for a period of six months from 10th February’ 2020 to 9th August’ 2020. The patients with vocal cord lesions were selected according to the eligibility criteria by purposive sampling. Results : On indirect laryngoscopic examinations, 29.89% were vocal cord polyp, 16.09% suspected vocal cord neoplasm, 14.94% vocal cord edema, 11.49% vocal cord nodule, 5.74% vocal cord palsy and 2.61 were ulcerative lesion of vocal cords whereas poor view were in 18.39% cases. On fibreoptic laryngoscopy (FOL), 29.89% were vocal cord polyp, 19.54% suspected vocal cord neoplasm, 17.24% vocal cord edema, 16.09% vocal cord nodule, 8.04% vocal cord palsy and 6.90% were ulcerative lesion of vocal cord. 2.30% revealed normal study. Study showed that fibreoptic laryngoscopic examination is superior to indirect laryngoscopy in diagnosing vocal cord lesions. Conclusion : Fibreoptic laryngoscopy (FOL) is significantly superior to indirect laryngoscopy in the diagnosis of vocal cord lesions. Indirect laryngoscopy sometimes may miss to diagnose a sinister disease like malignancy. Bangladesh J Otorhinolaryngol 2023; 29(1): 24-31
背景:音变是耳鼻喉科常见的主诉之一,声音嘶哑是音质改变最常见的症状。声音嘶哑总是直接或间接影响发声器官的最早表现。虽然声音嘶哑最常见的原因是良性的,其中最常见的是声音滥用,但我们应该经常调查更险恶的病理,如恶性肿瘤。本研究的目的是比较纤维喉镜(FOL)与间接喉镜在声带病变诊断中的诊断率。目的:比较纤维喉镜(FOL)与间接喉镜(间接喉镜)对声带病变的诊断价值。方法:这是一项横断面研究,在SSMC Mitford医院耳鼻喉科和头颈外科进行,样本量为87例,时间为2020年2月10日至2020年8月9日,为期6个月。采用有目的抽样的方法,根据入选标准选取声带病变患者。结果:间接喉镜检查中,29.89%为声带息肉,16.09%为疑似声带肿瘤,14.94%为声带水肿,11.49%为声带结节,5.74%为声带麻痹,2.61%为声带溃疡性病变,18.39%为视野不佳。纤维喉镜检查中,29.89%为声带息肉,19.54%为疑似声带肿瘤,17.24%为声带水肿,16.09%为声带小结,8.04%为声带麻痹,6.90%为声带溃疡性病变。2.30%显示正常。研究表明,纤维喉镜检查在诊断声带病变方面优于间接喉镜检查。结论:纤维喉镜对声带病变的诊断明显优于间接喉镜。间接喉镜检查有时可能误诊恶性肿瘤等恶性疾病。孟加拉国[J] otorhinolyngol 2023;(1): 29日24-31
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引用次数: 0
The Arts of Scientific Paper 科学论文的艺术
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68564
Ahmmad Taous
Abstract not available Bangladesh J Otorhinolaryngol 2023; 29(1): 01-04
[摘要]孟加拉[J];(1): 29日01-04
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引用次数: 0
Papillary Thyroid Carcinoma with Tracheal Invasion 甲状腺乳头状癌伴气管侵犯
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68135
Md Atiqur Rahman, Mohammed Abdus Sattar
Papillary thyroid carcinoma (PTC) is commonly associated with praising survivaland less recurrence rate compared with other malignancy. The prognosis of PTC depends on age, sex, size of tumor, lymphadenopathy, and extrathyroidal extension. PTC which invade upper aerodigestive tract (ADT) is more aggressive tumor that signify the patients at a greater risk of recurrence and death. Bangladesh J Otorhinolaryngol 2023; 29(1): 45-48
与其他恶性肿瘤相比,甲状腺乳头状癌(PTC)的生存率高,复发率低。PTC的预后取决于年龄、性别、肿瘤大小、淋巴结病变和甲状腺外扩张。PTC是侵袭上呼吸道消化道(ADT)的恶性肿瘤,具有较高的复发和死亡风险。孟加拉国[J] otorhinolyngol 2023;(1): 29日45-48
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引用次数: 0
Prevalence of Recurrence in Early Tongue Cancer T1 or T2 with or Without Neck Dissection 早期舌癌T1或T2伴或不伴颈部清扫的复发率
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68071
Md Momin Uddin, Sayed Farhan Ali Razib, Md Monsur Alam, Md Ali Azad
Background: Patients with T1 T2 N0 mouth or tongue cancer that has been confirmed by a doctor may choose to have a neck dissection. Some say that nodal return of a T1 original tumor is well controlled, while others say that salvage is more often the exception than the rule.Objective: To determine the likelihood of recurrence in T1 or T2 early tongue carcinoma with or without neck dissection.Methods: The prospective cross-sectional clinical study was conducted from March 2021 to March 2023 at the Department of ENT and Head Neck Surgery, Combined Military Hospital, Dhaka. All 100 patients who presented with clinically determined T1 and T2 disease, as defined by the American Joint Committee on Cancer (AJCC), were treated at the Department of Otolaryngology of the Combined Military Hospital in Dhaka and underwent primary surgical resection of the tumor with or without neck dissection. The study eliminated cases of cancer involving the base of the tongue or recurring oral tongue cancer.Results: In the neck dissection group, 3(6%) experienced local recurrence, 2(4%) experienced regional recurrence, and 1 (2%) experienced both (local and regional recurrence). There will be no dissection. 10(20%) Local recurrence, 3 (6%), Regional recurrence, and 1 (2% combined local and regional recurrence). Recurrence was 4(8%) in the neck dissection group and 14(28%) in the no dissection group.Conclusion: In this study, the overall recurrence rate was 8% in neck dissection and 28% in no neck dissection. The overall recurrence rate in the no neck dissection group was significantly greater than in the neck dissection group.Bangladesh J Otorhinolaryngol 2023; 29(1): 5-10
背景:经医生确诊的T1 T2 N0型口腔癌或舌癌患者可选择颈部清扫术。一些人认为T1原发肿瘤的结节性复发得到了很好的控制,而另一些人则认为挽救性肿瘤往往是例外而非常规。目的:探讨T1、T2期早期舌癌伴或不伴颈部清扫的复发率。方法:前瞻性横断面临床研究于2021年3月至2023年3月在达卡联合军队医院耳鼻喉科和头颈外科进行。根据美国癌症联合委员会(AJCC)的定义,所有100例临床确定为T1和T2疾病的患者均在达卡联合军事医院耳鼻喉科接受治疗,并接受原发性手术切除肿瘤,伴或不伴颈部清扫。该研究排除了涉及舌底或复发性口腔癌的癌症病例。结果:颈部清扫组局部复发3例(6%),局部复发2例(4%),局部和区域均复发1例(2%)。不会进行解剖。局部复发10例(20%),局部复发3例(6%),局部和局部合并复发1例(2%)。颈清扫组复发率为4例(8%),无清扫组为14例(28%)。结论:在本研究中,颈部清扫组的复发率为8%,未清扫组的复发率为28%。无颈清扫组的总复发率明显高于颈清扫组。孟加拉国[J] otorhinolyngol 2023;29 (1): 5 - 10
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引用次数: 0
Comparative Study of Temporalis Fascial Graft Medial or Lateral to Handle of Malleus in Tympanoplasty 鼓室成形术中踝内外侧颞筋膜移植物的比较研究
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68128
Timir Kumar Debnath, Aslam Hazari, Shahinur Arefeen, Wakilur Rahman, A K Datta, Abdus Samad
Objective: To asses and compare the hearing outcome and healing of Temporalis fascia graft in both groups by placing the graft medial (underlay technique) or lateral to the handle of malleus (over- underlay technique). Method: This retrospective study conducted for a period January,2018 to December 2019- Two years period in Specialized ENT Hospital (SENTH) of SAHIC (Society for assistance to hearing impaired Children), Dhaka. It includes 104 patients, Group-A 59 patients (Underlay technique) and Group-B 45 patients (Over-underlay technique). Result: Graft success rate overall 84.62%, Group-A- 84.75% (Medial to malleus) and Group-B- 84.44% (lateral to malleus). Pre- and post- operative air- bone gap of two groups were compared. Conclusion: Both techniques (medial or lateral to malleus handle) has a high rate of success for the closure of TM perforation with significant improvement in air-bone gap. Bangladesh J Otorhinolaryngol 2023; 29(1): 17-23
目的:评价和比较两组颞筋膜移植物内侧(下垫法)和外侧(上垫法)置放听骨的听力效果和愈合情况。方法:本回顾性研究于2018年1月至2019年12月在达卡saic(听力受损儿童援助协会)专科耳鼻喉科医院(SENTH)进行,为期两年。104例患者,a组59例(Underlay technology), b组45例(Over-underlay technology)。结果:移植成功率总体为84.62%,a组(内踝)为84.75%,b组(外踝)为84.44%。比较两组手术前后的气骨间隙。结论:两种技术(内踝或外踝柄)对TM穿孔闭合成功率高,气骨间隙明显改善。孟加拉国[J] otorhinolyngol 2023;(1): 29日17-23
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引用次数: 0
Repair of Surgical Defect by Pectoralis Major Flap Versus Free Radial Forearm Flap in Buccal Carcinoma: Assessment of Quality of Life 胸大肌皮瓣与游离前臂桡侧皮瓣修复颊癌手术缺损:生活质量评价
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68130
Mohammad Abdul Hamid, Belayat Hossain Siddiquee, Md Mosleh Uddin, Syed Farhan Ali Razib, Shah Sohel, Arif Mahmud Jewel
Background: Soft tissue reconstruction of the oral cavity is the most critical factor in achieving a successful functional result. Malignant lesions occurring in the buccal area are usually treated with primary surgical and/or radiotherapy of the head and neck region. Depending on the location and size of the buccal tumor, radical surgical treatment often affects all oral function such as speech, swallowing, chewing, oral rehabilitation, nutrition and appearance. To maximize postoperative function, flap repair is currently the preferred method for reconstruction of buccal defects after major surgery. Among the flaps most commonly used are pedicle pectoralis major myocutaneous flap and the free radial forearm fasciocutaneous flap. The choice of the best reconstructive option is still controversial. Objective: To find out the quality of life after repair of surgical defect by pectoralis major flap versus free radial forearm flap in buccal carcinoma. Methods: This prospective study was conducted in the department Otolaryngology- Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from September 2017 to August 2019. A total number of 44 cases of buccal carcinoma patient who had the inclusion criteria were enrolled as a study sample. These subjects were selected from the Department of Otolaryngology-Head & Neck Surgery, Department of Oral & Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, National Institute of ENT, Tejgaon, Dhaka. Comparison of nominal or ordinal variables between patients who have undergone surgery with either the RFFF or PMMF were analyzed using a chi-square test. The UW-QOL scores were compared for each domain using the nonparametric Mann-Whitney test. P-value < .05 was accepted as the level of significance. Results: In this study 40 out of 44 patients were completed UW-QOL questionnaires. The median age was 52 (range 40-65years), the male-female ratio was 1.44:1. All were habituated in either smoking or betel leaf/ nut or alcohol. Most of them were illiterate to the primary level of education and suffering from stage- iii tumor. All these variables were statistically insignificant except gender. Patients reconstructed with RFFF felt better in shoulder domains than PMMF but felt worse appearance domains and these were statistically significant in both 3 months and 6 months postoperatively. Conclusion: The study result had shown that reconstruction of the defect after buccal cancer resection using either RFFF or PMMF significantly influences patient’s quality of life. This study will provide valuable information for surgeons who will decide reconstruction modalities for buccal cancer and also will help the patients getting a better outcome. Bangladesh J Otorhinolaryngol 2023; 29(1): 32-38
背景:口腔软组织重建是实现口腔功能成功的最关键因素。发生在颊部的恶性病变通常通过头颈部的手术和/或放射治疗来治疗。根据口腔肿瘤的位置和大小,根治性手术治疗往往会影响所有的口腔功能,如言语、吞咽、咀嚼、口腔康复、营养和外观。为了最大限度地发挥术后功能,皮瓣修复是目前主要手术后颊缺损重建的首选方法。其中最常用的皮瓣是胸大肌蒂肌皮瓣和前臂桡骨游离筋膜肌皮瓣。最佳重建方案的选择仍然存在争议。目的:比较胸大肌皮瓣与前臂桡侧游离皮瓣修复颊癌手术缺损后的生活质量。方法:本前瞻性研究在耳鼻喉科进行。2017年9月至2019年8月,孟加拉谢赫穆吉布医科大学,达卡。共纳入44例符合纳入标准的颊癌患者作为研究样本。这些研究对象选自耳鼻喉科头科&口腔外科颈外科;Bangabandhu Sheikh Mujib医科大学,Shahbag,国家耳鼻喉科研究所,Tejgaon, Dhaka。采用卡方检验对接受RFFF或PMMF手术的患者的标称变量和序数变量进行比较。使用非参数Mann-Whitney检验比较每个领域的UW-QOL分数。假定值& lt;0.05为显著性水平。结果:44例患者中有40例完成了UW-QOL问卷。年龄中位数为52岁(40-65岁),男女比例为1.44:1。所有人都习惯吸烟或槟榔叶/坚果或酒精。他们大多是初等文化程度的文盲,患有iii期肿瘤。除性别外,其他变量均无统计学意义。术后3个月和6个月,RFFF重建患者的肩域感觉优于PMMF重建患者,但外观域感觉较差。结论:本研究结果表明,颊癌切除术后缺损的重建,无论是RFFF还是PMMF,都能显著影响患者的生活质量。本研究将为外科医生决定口腔肿瘤的重建方式提供有价值的信息,也将帮助患者获得更好的结果。孟加拉国[J] otorhinolyngol 2023;(1): 29日
{"title":"Repair of Surgical Defect by Pectoralis Major Flap Versus Free Radial Forearm Flap in Buccal Carcinoma: Assessment of Quality of Life","authors":"Mohammad Abdul Hamid, Belayat Hossain Siddiquee, Md Mosleh Uddin, Syed Farhan Ali Razib, Shah Sohel, Arif Mahmud Jewel","doi":"10.3329/bjo.v29i1.68130","DOIUrl":"https://doi.org/10.3329/bjo.v29i1.68130","url":null,"abstract":"Background: Soft tissue reconstruction of the oral cavity is the most critical factor in achieving a successful functional result. Malignant lesions occurring in the buccal area are usually treated with primary surgical and/or radiotherapy of the head and neck region. Depending on the location and size of the buccal tumor, radical surgical treatment often affects all oral function such as speech, swallowing, chewing, oral rehabilitation, nutrition and appearance. To maximize postoperative function, flap repair is currently the preferred method for reconstruction of buccal defects after major surgery. Among the flaps most commonly used are pedicle pectoralis major myocutaneous flap and the free radial forearm fasciocutaneous flap. The choice of the best reconstructive option is still controversial. Objective: To find out the quality of life after repair of surgical defect by pectoralis major flap versus free radial forearm flap in buccal carcinoma. Methods: This prospective study was conducted in the department Otolaryngology- Head &amp; Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from September 2017 to August 2019. A total number of 44 cases of buccal carcinoma patient who had the inclusion criteria were enrolled as a study sample. These subjects were selected from the Department of Otolaryngology-Head &amp; Neck Surgery, Department of Oral &amp; Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, National Institute of ENT, Tejgaon, Dhaka. Comparison of nominal or ordinal variables between patients who have undergone surgery with either the RFFF or PMMF were analyzed using a chi-square test. The UW-QOL scores were compared for each domain using the nonparametric Mann-Whitney test. P-value < .05 was accepted as the level of significance. Results: In this study 40 out of 44 patients were completed UW-QOL questionnaires. The median age was 52 (range 40-65years), the male-female ratio was 1.44:1. All were habituated in either smoking or betel leaf/ nut or alcohol. Most of them were illiterate to the primary level of education and suffering from stage- iii tumor. All these variables were statistically insignificant except gender. Patients reconstructed with RFFF felt better in shoulder domains than PMMF but felt worse appearance domains and these were statistically significant in both 3 months and 6 months postoperatively. Conclusion: The study result had shown that reconstruction of the defect after buccal cancer resection using either RFFF or PMMF significantly influences patient’s quality of life. This study will provide valuable information for surgeons who will decide reconstruction modalities for buccal cancer and also will help the patients getting a better outcome. Bangladesh J Otorhinolaryngol 2023; 29(1): 32-38","PeriodicalId":53915,"journal":{"name":"Bangladesh Journal of Otorhinolaryngology","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiological Effect of Enlarged Adenoid on Middle Ear in Children 儿童中耳腺样体肿大的病理生理作用
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68075
Mohammad Shahjahan Sarker, ABM Delowar Hossain, Mashuque Mahmud, Mahmudul Hasan, Mohammad Anamul Haque, Mani Lal Aich
Objective: To identify the incidence of otitis media with effusion (OME) in children with enlarged adenoid. Methodology: This is a cross sectional observational study was carried out at Department of Otolaryngology and Head Neck surgery of Sir Salimullah Medical College Mitford Hospital, Dhaka from July 2014 to June 2016. One Hundred and Fifty (150) children with enlarged adenoid were included in this study. All patients were subjected for history, local physical examination, evaluation of adenoid size by X ray of nasopharynx lateral view. Pure tone audiometry & tympanometry were done in all patients. Informations were recorded in a specially designed data collection sheet. Result: Among 150 children with enlarged adenoid 30(20%) patient had OME, majority of patients (60%) were age group 7-9 years. Male were predominant (60%) than female (40%). Among 150 patients grade- I was 16%, grade II- was 26%, grade-III was 54% and grade IV was 4%.According to the grading of enlarged adenoid cases , grade I, grade II , grade III and grade IV had 8.33%,15.38% ,23.46% and 50% cases had OME respectively. Hearing loss was in 33(22%) children. According to tympanometry, type A curve was in 118(78.67%) children, type B 26(17.33%) and type C 6(4%) children. Conclusion: Enlarged adenoid is associated with otitis media with effusion. Incidence of Otitis media with effusion increases with the proportion of severity of nasopharyngeal obstruction by enlarged adenoid. Bangladesh J Otorhinolaryngol 2023; 29(1): 11-16
目的:探讨儿童腺样体肿大并发渗出性中耳炎(OME)的发生率。方法:这是一项横断面观察性研究,于2014年7月至2016年6月在达卡萨里穆拉爵士医学院米特福德医院耳鼻喉科和头颈外科进行。150名患有腺样体肿大的儿童被纳入本研究。所有患者均接受病史、局部体格检查、鼻咽侧位X线片评估腺样体大小。纯音测听所有患者均行鼓室测量。信息记录在专门设计的数据收集表中。结果:150例儿童腺样体肿大患者中有30例(20%)发生OME,其中以7 ~ 9岁年龄组居多(60%)。男性占多数(60%),女性占40%。在150例患者中,I级占16%,II级占26%,iii级占54%,IV级占4%。根据腺样体肿大病例的分级,ⅰ级、ⅱ级、ⅲ级和ⅳ级分别占8.33%、15.38%、23.46%和50%。33名(22%)儿童有听力损失。其中A型118例(78.67%),B型26例(17.33%),C型6例(4%)。结论:腺样体肿大与中耳炎伴积液有关。中耳炎伴积液的发生率随腺样体增大引起的鼻咽阻塞严重程度的增加而增加。孟加拉国[J] otorhinolyngol 2023;29 (1): 16
{"title":"Pathophysiological Effect of Enlarged Adenoid on Middle Ear in Children","authors":"Mohammad Shahjahan Sarker, ABM Delowar Hossain, Mashuque Mahmud, Mahmudul Hasan, Mohammad Anamul Haque, Mani Lal Aich","doi":"10.3329/bjo.v29i1.68075","DOIUrl":"https://doi.org/10.3329/bjo.v29i1.68075","url":null,"abstract":"Objective: To identify the incidence of otitis media with effusion (OME) in children with enlarged adenoid. Methodology: This is a cross sectional observational study was carried out at Department of Otolaryngology and Head Neck surgery of Sir Salimullah Medical College Mitford Hospital, Dhaka from July 2014 to June 2016. One Hundred and Fifty (150) children with enlarged adenoid were included in this study. All patients were subjected for history, local physical examination, evaluation of adenoid size by X ray of nasopharynx lateral view. Pure tone audiometry &amp; tympanometry were done in all patients. Informations were recorded in a specially designed data collection sheet. Result: Among 150 children with enlarged adenoid 30(20%) patient had OME, majority of patients (60%) were age group 7-9 years. Male were predominant (60%) than female (40%). Among 150 patients grade- I was 16%, grade II- was 26%, grade-III was 54% and grade IV was 4%.According to the grading of enlarged adenoid cases , grade I, grade II , grade III and grade IV had 8.33%,15.38% ,23.46% and 50% cases had OME respectively. Hearing loss was in 33(22%) children. According to tympanometry, type A curve was in 118(78.67%) children, type B 26(17.33%) and type C 6(4%) children. Conclusion: Enlarged adenoid is associated with otitis media with effusion. Incidence of Otitis media with effusion increases with the proportion of severity of nasopharyngeal obstruction by enlarged adenoid. Bangladesh J Otorhinolaryngol 2023; 29(1): 11-16","PeriodicalId":53915,"journal":{"name":"Bangladesh Journal of Otorhinolaryngology","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135202505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Familial Hypocalciuric Hypercalcemia 家族性低钙高钙血症1例
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-18 DOI: 10.3329/bjo.v29i1.68132
Muhammad Rasedul Hasan Bulbul, Mohammed Abdus Sattar
Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is the leading benign cause of hypercalcemia. It may occur due to autonomous hypersecretion of parathyroid hormone (PTH), independently of serum calcium levels. Familial hypocalciuric hypercalcemia (FHH) is a group of autosomal dominant rare genetic diseases only affecting the regulation of calcium metabolism. It is usually caused by one of many heterozygous missense mutations in the calcium-sensing receptor (CaSR) gene, which could up-regulate the set point of parathyroid cells. When the CaSR receptor is inactivated, PTH is not suppressed despite relatively high calcium, which makes FHH similar to PHPT. We present a unique case of concomitant FHH and suspected parathyroid adenoma. Case summary: A 10-year-old girl with symptomatic severe hypercalcemia, high PTH, and genetically diagnosed as FHH was referred to the department of otolaryngologyhead and neck surgery due to surgical excision of suspected parathyroid adenoma. Her biochemical evaluation showed elevated serum calcium and PTH. The calcium– creatinine clearance ratio was >0.01 (0.16). Her parathyroid scintigraphy showed negative for parathyroid adenoma, but the ultrasonography of the neck revealed an enlarged right inferior parathyroid gland. She underwent surgical excision of both the right superior and inferior parathyroid glands. However, the patient’s serum calcium and parathyroid hormone increased in the postoperative period, and her symptoms remained unchanged. Conclusion: The correct diagnosis of the underlying cause of hypercalcemia is essential to ensure the proper treatment. Patients with FHH should avoid operative treatment, and PHPT should be differentiated to determine whether surgery should include parathyroidectomy with the removal of suspected parathyroid adenoma. Bangladesh J Otorhinolaryngol 2023; 29(1): 39-44
背景:原发性甲状旁腺功能亢进(PHPT)是一种常见的内分泌疾病,是导致高钙血症的主要良性原因。它可能是由于自主分泌甲状旁腺激素(PTH),独立于血清钙水平。家族性低钙性高钙血症(FHH)是一组常染色体显性遗传病,仅影响钙代谢调节。它通常是由钙敏感受体(CaSR)基因的杂合错义突变之一引起的,该突变可上调甲状旁腺细胞的设定点。当CaSR受体失活时,尽管钙含量相对较高,但PTH不受抑制,这使得FHH与PHPT相似。我们提出一个独特的病例合并FHH和怀疑甲状旁腺腺瘤。病例总结:一名10岁女孩,有症状的严重高钙血症,高甲状旁腺激素,遗传诊断为FHH,因手术切除疑似甲状旁腺瘤而转至耳鼻喉头颈外科。生化检查显示血钙和甲状旁腺激素升高。钙-肌酐清除率为>0.01(0.16)。她的甲状旁腺造影显示甲状旁腺腺瘤阴性,但颈部超声显示右下甲状旁腺肿大。她接受手术切除右上、下甲状旁腺。但术后患者血清钙、甲状旁腺激素升高,症状无变化。结论:正确诊断高钙血症的病因是保证正确治疗的关键。FHH患者应避免手术治疗,并应区分PHPT,以确定手术是否应包括甲状旁腺切除术并切除疑似甲状旁腺瘤。孟加拉国[J] otorhinolyngol 2023;(1): 29日39-44
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引用次数: 0
Evolution in the Management of Laryngotracheal Stenosis 喉气管狭窄治疗的进展
IF 0.1 Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-03-02 DOI: 10.3329/bjo.v28i2.64293
S. Rahman
Abstract not available Bangladesh J Otorhinolaryngol 2022; 28(2): 118-126
摘要不可用孟加拉耳鼻喉科杂志2022;28(2):118-126
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引用次数: 0
Clinicopathological Study of Supraglottic Laryngeal Malignancies 声门上喉恶性肿瘤的临床病理研究
IF 0.1 Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-03-02 DOI: 10.3329/bjo.v28i2.64297
Milon Kazi, Md Iqbal Hossen, Fazle Elahi Jonaed, IM Hashim Reza Roktim, Mirza Kaisar Elahi, M. Chowdhury
Background: Laryngeal malignancy is the second most common malignancy in head neck region worldwide. Incidence of supraglottic carcinoma is more common in this country which interferes with most vital functions in the sufferers like voice, respiration and swallowing by virtue of its anatomical location, local infiltration and direct extension. Objectives: To find out the clinicopathological profile of supraglottic laryngeal malignancies of the patients attending in a tertiary level Hospital. Methods: A cross sectional study was conducted among seventy eight cases of supraglottic carcinoma who were histopathologically proven selected from the in-patient department of ENT and Head -Neck Surgery Dhaka Medical College Hospital, Dhaka during January 2020 to July 2021. Results: Among 78 cases in this study, male: female ratio 10.1:1 and mean age was 52.1 (± 4.6) years with the range from 40 to 78 years. Majority of the patients came from low socioeconomic condition (79.5%). Regarding habit 93.6% of cases were smoker and 59% are habituated in chewing betel nut and leaves, 3.8% were with chewing tobacco and alcohol 2.6%. Most of patients presented with more than one symptom and the commonest was change of voice (87.2%), which followed by dysphagia (78.2%), neck swelling (55.1%), irritable cough (32%) and dyspnoea (20.5%). A big portion of the patients (39.7%) had T2 lesion followed by T3 lesion (38.5%), T1 lesion (11.5%) and T4 lesion (10.3%) clinically. Clinical nodal involvement presented in 55.1% cases and there was no distance metastasis. 56 (71.8%) patients had exophytic growth and 22 (28.2%) patients had ulcerative growth. A large portion of the patients (65.4%) had growth in Aryepiglottic fold followed by False Cord (34.6%), arytenoid (29.5%) and Epiglottis (25.6%). On histopathological evaluation, Squamous cell carcinoma (SCC) was present in 85.8% cases, well differentiated (14.1%), moderately differentiated (53.8%), and poorly differentiated (17.9%). While Adenocarcinoma found in 7.7% cases and Non-Hodgkin Lymphoma present in 6.4% cases. Conclusion: Supraglottic carcinoma usually occurs in 5th decade with male predominancy in poor socio economic group. Smoking, chewing (tobacco and betel nut) habits and alcohol consumption have got strong relation in the causation of supraglottic carcinoma.More than half of the cases has nodal metastasis and predominant histological type was squamous cell carcinoma.  Bangladesh J Otorhinolaryngol 2022; 28(2): 141-148
背景:喉恶性肿瘤是全球头颈部第二常见的恶性肿瘤。声门上癌在我国发病率较高,由于其解剖位置、局部浸润、直接延伸等特点,声门上癌干扰了患者的发声、呼吸、吞咽等重要功能。目的:了解某三级医院声门上喉恶性肿瘤的临床病理特点。方法:对2020年1月至2021年7月在达卡医学院附属医院耳鼻喉科和头颈外科住院部经组织病理学证实的78例声门上癌患者进行横断面研究。结果:本组78例患者,男女比例为10.1:1,平均年龄52.1(±4.6)岁,年龄范围40 ~ 78岁。以社会经济条件较差的患者居多(79.5%)。在习惯方面,93.6%的病例吸烟,59%的病例习惯咀嚼槟榔和叶子,3.8%的病例习惯咀嚼烟草和酒精2.6%。大多数患者表现为一种以上症状,最常见的是声音改变(87.2%),其次是吞咽困难(78.2%)、颈部肿胀(55.1%)、易激咳嗽(32%)和呼吸困难(20.5%)。临床上以T2病变为主(39.7%),其次为T3病变(38.5%)、T1病变(11.5%)、T4病变(10.3%)。临床淋巴结累及55.1%,无远处转移。56例(71.8%)患者有外生性生长,22例(28.2%)患者有溃疡性生长。大部分患者(65.4%)生长在Aryepiglottic襞,其次是假索(34.6%)、杓状(29.5%)和会厌(25.6%)。在组织病理学评估中,鳞状细胞癌(SCC)出现在85.8%的病例中,高分化(14.1%),中分化(53.8%)和低分化(17.9%)。腺癌占7.7%,非霍奇金淋巴瘤占6.4%。结论:声门上癌多发生于5 ~ 10岁,社会经济条件较差的人群以男性为主。吸烟、咀嚼(烟草和槟榔)习惯和饮酒与声门上癌的发病有密切关系。超过一半的病例有淋巴结转移,主要的组织学类型为鳞状细胞癌。孟加拉国[J] otorhinolyngol 2022;28 (2): 141 - 148
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Bangladesh Journal of Otorhinolaryngology
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