The Association between Serum Levels of Ferritin and D-Dimer with Liver Function Tests in Patients with COVID-19

Abstract

Background: SARS-Cov-2, the culprit responsible for the 2019 new coronavirus disease (COVID-19), has posed a serious threat to worldwide public health. At the moment, it is estimated that the novel coronavirus severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has infected It has infected a huge number of people worldwide and is responsible for the clinical syndrome of coronavirus sickness 2019 (COVID-19). Although the primary clinical manifestation is pulmonary disease, mounting evidence supports the involvement of multiple organ systems, including the Gastro Intestinal (GI) tract and liver. To evaluate the potential changes in liver function tests, and their association with illness severity and mortality in patients with COVID-19. Materials and methods: This case-control study of 90 subjects were included, 60 patients admitted to Merjan Hospital, Babel, Iraq infected with COVID-19 and 30 samples of healthy subjects as a control group. The serum levels of ALT, AST, Alp, and albumin were measured by colorimetric methods. Serum ferritin and d-dimer were measured by ichroma, and CBC conducting a statistical analysis and associated with the severity of disease. Results: In this study, the results demonstrated a significant increase in levels of ALT, AST, ALP, ferritinin, and D-dimer in patients compared with the healthy group. Levels of serum ferritin have a significant positive correlation with D-dimer, ALP, AST, ALT, and NLR levels. While, it has a significant negative correlated with serum albumin in patients with corona virus group. The neutrophil percentage significantly higher than normal. While, the lymphocyte percentage was significantly lower in patients with elevated ferritin and d-dimer levels than the healthy group. Conclusion: COVID-19 patients with abnormal liver function testes are common in hospitalized patients with COVID-19, and associated with illness severity and rate of death as a higher incidence of severity illness and liver injury in patients with increased levels of serum ferritin, and D-dimer. © 2021 Norman WA, et al.