Experience of the Use of Photodynamic Therapy in the Treatment of Chronic Traumatic Lesions of Oral Mucosa

Abstract

Aim: To evaluate the therapeutic effectiveness of the use of photodynamic therapy in chronic traumatic lesions of oral mucosa. Materials and methods: Clinical examination and treatment of 67 patients aged 18-65 years with erosive-ulcerative lesions of oral mucosa were carried out. Treatment of patients in the main group was performed using photodynamic therapy. Treatment of patients of the control group was carried out according to the standard method. The results of treatment were evaluated by clinical and cytological parameters. Results: In all patients of the main group with chronic traumatic erythema, already on the second day of treatment, complaints of pain when talking and eating completely disappeared, and on the third day in 100% of patients the affected mucosa had no pathological changes. In patients with erosive-ulcerative lesions, complete clinical recovery in the main group was observed on the 3-4th day of treatment, in the control group – on the 7-10th day. The results of cytological examination, namely the absence of young epithelial cells of stages 1 and 2 of differentiation, a significant decrease of intermediate maturity cells (stages 3 and 4) and a similar increase of mature cells (stages 5 and 6), indicated the acceleration of mucosal regeneration in patients of the main group compared to the control group. Conclusions: The use of photodynamic therapy in the treatment of traumatic oral mucosa lesions contributed to the acceleration of elimination of clinical manifestations of chronic mechanical injuries and the normalization of parameters of cytological characteristics of epithelial cells in patients of the main group compared to the group of standard treatment.