Comparative Analysis of Complex Programs of Renewal Treatment of Patients with Chronic Pancreatitis

IF 0.3 Q4 REHABILITATION Acta Balneologica Pub Date : 2023-01-01 DOI:10.36740/abal202301106
L. Babinets, Z. Sabat, Olha Salamadze, Zoreslava Ya. Onufryk
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Abstract

Aim: To conduct a comparative analysis of the dynamics of heart rate variability parameters in CP patients with autonomic dysfunction under the influence of the proposed complex treatment programs with the additional inclusion of the vegetative stabilizing agent memoplant and a combination of complex bioregulatory drugs. Materials and Methods: Statistical and spectral parameters of heart rate variability were analyzed in 69 patients with CP before and after outpatient treatment. Patients were divided into 3 groups of 23 patients with CP: group 1 – received conventional treatment (CT) according to the clinical diagnosis and the protocol proposed by the Ministry of Health of Ukraine (Order No. 638 of 10.09.2014); group 2 – CT enhanced with a course of the vegetative-stabilizing drug ginkgo biloba (memoplant); 3 group – CT with a course of memoplant and complex bioregulatory therapy (BRT): momordica compositum, traumeel S and neurexan according to the proposed scheme. Results: In group 1, the stress index (SI) decreased by 18.49%, p<0.05, vegetative reactivity (VR) increased by 21.31%, p<0.05, IARS decreased by 25.79%, p<0.01. In group 2, a more significant decrease in sympathicotonia was observed: SI decreased by 38.17% (p<0.01), mode amplitude (АМо) by 14.57% (p<0.05), the range of variation (X) increased by 12.78% (p<0.05); IARS decreased by 44.55 % (p<0.01) to moderate tension. There was an increase in the total spectrum power (TP) (by 29.21%, p<0.01) and components: LF increased by 37.03% (p<0.01) relative to the initial level, HF by 64.01% (p<0.01), VLF by 8.75% (p<0.05). In patients of group 3, normalization of SI and АМо was observed (indicators decreased by 48.42% and 19.98%, p<0.01), X increased by 17.35%, p<0.01; The VR level did not differ significantly from the control (1.16±0.06 and 1.25±0.10, respectively). IARS decreased by 56.18% (p<0.01); TP increased by 49.61% (p<0.01), LF by 76.78% (p<0.01), HF by 117.67% (p<0.01), VLF by 8.41% (p<0.05). Conclusions: In patients with CP, a higher efficiency of treatment programs with the inclusion of ginkgo biloba and complex bioregulatory therapy on the state of autonomic regulation was established compared to the generally accepted program in terms of spectral and statistical parameters of heart rate variability.
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慢性胰腺炎患者复诊综合方案的比较分析
目的:比较分析合并植物稳定剂备忘录植物和复合生物调节药物的复合治疗方案对CP合并自主神经功能障碍患者心率变异性参数的影响。材料与方法:对69例CP患者门诊治疗前后心率变异性的统计参数和频谱参数进行分析。将23例CP患者分为3组:1组-根据临床诊断和乌克兰卫生部提出的方案(2014年9月10日第638号命令)进行常规治疗(CT);2组CT增强,给予一个疗程的植物稳定药物银杏叶(memoplant);3组- CT联合一个疗程的记忆植物和复杂生物调节治疗(BRT):根据建议方案,罗摩复方、曲美尔S和诺瑞康。结果:1组应激指数(SI)降低18.49%,p<0.05;营养反应性(VR)提高21.31%,p<0.05; IARS降低25.79%,p<0.01。2组交感张力下降更明显:SI下降38.17% (p<0.01),模态振幅(АМо)下降14.57% (p<0.05),变异幅度(X)增加12.78% (p<0.05);中度张力组IARS下降44.55% (p<0.01)。总谱功率(TP)和成分均较初始水平增加了29.21% (p<0.01),其中LF增加了37.03% (p<0.01), HF增加了64.01% (p<0.01), VLF增加了8.75% (p<0.05)。3组患者SI、АМо恢复正常(指标分别下降48.42%、19.98%,p<0.01), X升高17.35%,p<0.01;VR水平与对照组无显著差异(分别为1.16±0.06和1.25±0.10)。IARS降低56.18% (p<0.01);TP升高49.61% (p<0.01), LF升高76.78% (p<0.01), HF升高117.67% (p<0.01), VLF升高8.41% (p<0.05)。结论:在CP患者中,在心率变异性的频谱和统计参数方面,银杏叶联合复杂生物调节治疗方案对自主调节状态的影响优于一般接受的方案。
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来源期刊
Acta Balneologica
Acta Balneologica REHABILITATION-
自引率
66.70%
发文量
58
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