Effect of Laurusnobilis extract and Atorvastatin on Liver and Kidney function of Hyperlipidemia Male Rats

Abstract

Introduction: Hyperlipidemia associated with increase of atherosclerosis and heart, blood vessels diseases. the present study was discuss of potentials effect of bay leave extract (BLE) and atorvastatin drug at diet with high fat, feeding rat types. Material and Methods: The Rats were randomly classificationfor 4 groups each group have 10 rats. control feed standard diet, group two rats feed HFD, group three rats feed HFD + ( BLE 250mg/kg ) and group four rats feed HFD + Atorvastatin 20 mg/kg in the experiment, the treatment done by gavage and treated with 4 weeks daily. Results and Conclusion : The results show increased significantly at the end body weights also the weight gain at group two by treated (HFD) , while hepatic levels was inhibited for the cholesterol, and also triglycerides, also the low-density lipoprotein cholesterol; While the hepatic levels and serum of high-density lipoprotein cholesterol may be increased when the animal treated 250 mg/kg BLE and 20mg/kg atorvastatin , also the result showed increased significantly in serum AST ,ALT, ALP, urea and creatinine in group of animals treated HFD , and caused decreased significantly in the value of above parameters when the animals treated 250 mg/kg BLE and 20mg/kg atorvastatin ,it reach the control. In conclusion, bay leave exerts and atorvastatin have amelioration effect against hyperlipidemia in HFD-fed rats.