Musa paradisiaca L. May Restore Pancreatic Morphology and Function to Trigger its Anti-Diabetic and Hypolipidemic Activities in Alloxon-Induce Diabetic Rats

Abstract

Prevalence of diabetes mellitus is on steady rise, though several therapeutic options are available to treat diabetes mellitus. Medicinal plants are in use alongside prescribed therapies; however more research on medicinal plants is warranted to retrieve their anti-diabetic mechanisms to develop low cost, safe and effective anti-diabetic drugs. Aim of current study is to (a) determine antidiabetic and hypolipidemic potential of organic extract of Musa paradisiaca L. (b) to retrieve underlying mechanisms responsible for anti-diabetic effects triggered by the plant. Alloxan was used to induce diabetes mellitus in rates. Two standard drugs (Glibenclamide 2.5 mg/kg, insulin 4 U/200 mg/dl blood glucose) and various doses of organic plant extract from different morphological parts (100 mg/kg, 250 mg/kg and 500 mg/kg) were administered orally to the groups of healthy and diabetic rats for 20 days. ANOVA followed by t-test was used for the statistical analysis. Organic extract from Musa paradisiaca L. flowers and tracheal fluid have significant hypoglycemic activity. Significantly reduce the levels of bad cholesterol (LDL) while significantly enhance healthy cholesterol (HDL) levels in diabetes rats. Moreover, Organic extract from Musa paradisiaca L. flowers and tracheal fluid may restore normal morphology in the diabetic rats. It is concluded that organic extract of the plant trigger hypoglycemic and hypolipidemic activities possibly through restoring normal morphology and the pancreatic performance in diabetic rats.