{"title":"The interaction between 2019-nCoV and interferon I","authors":"J. Guan, Z. Chen, H. Zhu","doi":"10.3760/cma.j.issn.1674-2397.2021.02.004","DOIUrl":null,"url":null,"abstract":"COVID-19 has swept across the world, causing widespread epidemics and millions of life lost worldwide. After infected with 2019-nCoV, the body quickly mobilizes the innate immune response and produces type Ⅰ interferon (IFN-Ⅰ). IFN-Ⅰ plays an important role in virus clearance in the early stage of disease. This article reviews the innate immune recognition after virus infection and the interaction between 2019-nCoV and IFN-Ⅰ, which would be conductive to understanding the pathogenesis and antiviral treatment of COVID-19. © 2021 Chinese Medical Association","PeriodicalId":52394,"journal":{"name":"中华临床感染病杂志","volume":"14 1","pages":"97-101"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华临床感染病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/cma.j.issn.1674-2397.2021.02.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
新型冠状病毒与干扰素I的相互作用
2019冠状病毒病席卷全球，造成广泛流行，全球数百万人丧生。感染新型冠状病毒后，机体迅速调动先天免疫反应，产生Ⅰ型干扰素(IFN-Ⅰ)。IFN-Ⅰ在疾病早期的病毒清除中起重要作用。本文综述了2019-nCoV感染后的先天免疫识别以及与IFN-Ⅰ的相互作用，有助于了解COVID-19的发病机制和抗病毒治疗。©2021中华医学会
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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