The interaction between 2019-nCoV and interferon I

J. Guan, Z. Chen, H. Zhu
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引用次数: 0

Abstract

COVID-19 has swept across the world, causing widespread epidemics and millions of life lost worldwide. After infected with 2019-nCoV, the body quickly mobilizes the innate immune response and produces type Ⅰ interferon (IFN-Ⅰ). IFN-Ⅰ plays an important role in virus clearance in the early stage of disease. This article reviews the innate immune recognition after virus infection and the interaction between 2019-nCoV and IFN-Ⅰ, which would be conductive to understanding the pathogenesis and antiviral treatment of COVID-19. © 2021 Chinese Medical Association
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新型冠状病毒与干扰素I的相互作用
2019冠状病毒病席卷全球,造成广泛流行,全球数百万人丧生。感染新型冠状病毒后,机体迅速调动先天免疫反应,产生Ⅰ型干扰素(IFN-Ⅰ)。IFN-Ⅰ在疾病早期的病毒清除中起重要作用。本文综述了2019-nCoV感染后的先天免疫识别以及与IFN-Ⅰ的相互作用,有助于了解COVID-19的发病机制和抗病毒治疗。©2021中华医学会
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来源期刊
中华临床感染病杂志
中华临床感染病杂志 Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
1445
期刊介绍: Chinese Journal of Clinical Infectious Diseases started its publication in April 2008. It had been indexed by CSTPCD of Institute of Scientific and Technical Information of China(ISTIC), Chinese Science Citation Database (CSCD), American Chemical Abstract (CA),Western Pacific Region Index Medicus(WPRIM), CNKI, Wanfang Data, Statistical Journal of China Academic Journal Impact Factor Annual Report,etc. The highest impact factor was 1.359, and the comprehensive quality of the journal ranked second in the field of infectious diseases in 2017. The article has been selected as one hundred excellent papers of Chinese medicine in 2018 and 2020, respectively. The journal is available both in print and online.
期刊最新文献
Research progress on the mechanism of multiple organ dysfunction in patients with COVID-19 The interaction between 2019-nCoV and interferon I Risk factors for fatal outcome in patients with severe COVID-19: an analysis of 107 cases in Wuhan Clinical features and chest CT findings in moderate and severe COVID-19 patients: an analysis of 506 cases from Wuhan Huoshenshan Hospital Early antiviral therapy of abidor combined with lopinavir/ritonavir and re-combinant interferonα-2b in patients with novel coronavirus pneumonia in Zhejiang: A multicenter and prospective study/ 中华临床感染病杂志
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