Non Compliance and Non Adherence to Antiretroviral Therapy (Art) at Kitwe Teaching Hospital

Ronald Moondoma, S. Siziya
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Abstract

It is widely recognized that adherence to antiretroviral therapy is critical to long-term treatment success, yet rates of adherence to antiretroviral medications are frequently sub-therapeutic. The objective of this study will be to determine the factors that contribute to the nonadherence and noncompliance to antiretroviral therapy. This study will be important in that it will help identify the different factors that lead to noncompliance and the various ways these factors can be combated so as to reduce the number of people dying from HIV/AIDS related causes and also help achieve the 90-90-90 treatment plan of the WHO. The number of deaths that are recorded due to AIDS affect the country as a whole in that they are an obstacle to social economic development hence all interventions possible must be put in place to reduce the mortality of AIDS which can also be from noncompliance to Highly active anti retro viral therapy. Some of the factors associated with noncompliance to HAART have been found to be behavioural, structural, and psychosocial barriers such as depression and other mental illnesses, neurocognitive impairment, low health literacy, low levels of social support, stressful life events, high levels of alcohol consumption and active substance use, homelessness, poverty, nondisclosure of HIV serostatus to those around them, denial, stigma, and inconsistent access to medications. This proposed study will be a casecontrol study. The methodology that will be used in the study will include using data from the ART clinic at Kitwe Teaching Hospital of the patients that are on HAART.
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Kitwe教学医院的不遵守和不坚持抗逆转录病毒治疗
人们普遍认识到,坚持抗逆转录病毒治疗对长期治疗的成功至关重要,但坚持抗逆转录病毒药物的比率往往是亚治疗。本研究的目的是确定导致抗逆转录病毒治疗不依从性和不依从性的因素。这项研究将是重要的,因为它将有助于确定导致不遵守的不同因素,以及这些因素可以对抗的各种方式,从而减少死于艾滋病毒/艾滋病相关原因的人数,也有助于实现世界卫生组织的90-90-90治疗计划。由于艾滋病而记录的死亡人数影响到整个国家,因为它们是社会经济发展的障碍,因此必须采取一切可能的干预措施,以降低艾滋病的死亡率,这也可能是由于不遵守规定而进行的高度积极的抗逆病毒治疗。与不遵守高效抗逆转录病毒疗法有关的一些因素已被发现是行为、结构和社会心理障碍,如抑郁症和其他精神疾病、神经认知障碍、卫生知识水平低、社会支持水平低、生活压力大、大量饮酒和使用活性物质、无家可归、贫困、不向周围人披露艾滋病毒血清状况、拒绝接受、污名化和不一致地获得药物。本研究将是一项病例对照研究。该研究将使用的方法将包括使用Kitwe教学医院抗逆转录病毒治疗诊所接受HAART治疗的患者的数据。
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