High-resolution phantom of a nephron for radiation nephrotoxicity evaluation in biophysical simulations

IF 1.1 Q4 BIOPHYSICS AIMS Biophysics Pub Date : 2022-01-01 DOI:10.3934/biophy.2022013
Masoud Jabbary, H. Rajabi
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Abstract

Computer simulation plays an important role in medical physics. The aim of this study was to generate an accurate model to calculate the absorbed dose at the cell level in a voxelized phantom of nephrons. In order to implement a model of kidney microdosimetry, a 3D mesh phantom of a human kidney nephron, representing a cortical nephron, was digitized to create a 3D voxelized phantom of a nephron for use in Monte Carlo simulations. The phantom was fed to GATE Monte Carlo toolkits, and simulations were performed to calculate the absorbed dose/energy from alpha and electron sources over a range of energy levels. The results were compared to the results published in literature that were derived by using a stylized phantom. The dose estimated in subunits of the voxelized and stylized phantoms showed a considerable bias (average of relative differences). The maximum difference for self-absorption was 12.5%, and up to 20% for cross-absorption. The digital phantom showed very significant differences in dose distribution among the cells in different subunits of the nephron. The results demonstrated that a small dissimilarity in the size and shape of subunits can lead to a considerable difference in the microdosimetry results. The model presented in this study offers a phantom that not only presents the realistic geometry of a nephron, which has been neglected in previous stylized models, but also one that has the capability of plotting the spatial distribution of the absorbed dose for any distribution of radiopharmaceuticals in nephron cells.
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生物物理模拟中用于辐射肾毒性评估的高分辨率肾元模型
计算机模拟在医学物理学中起着重要的作用。本研究的目的是建立一个精确的模型来计算肾元体素化幻体在细胞水平上的吸收剂量。为了实现肾脏微剂量学模型,将代表皮质肾元的人体肾元三维网格幻影数字化,以创建用于蒙特卡罗模拟的肾元三维体素幻影。将该模型送入GATE蒙特卡罗工具包,并进行模拟以计算在一定能级范围内α源和电子源的吸收剂量/能量。将结果与文献中发表的使用程式化幻像得出的结果进行比较。体素化和程式化幻影亚单位估计的剂量显示出相当大的偏差(相对差异的平均值)。自吸收差异最大可达12.5%,交叉吸收差异最大可达20%。数字幻影在肾元不同亚单位细胞间的剂量分布有显著差异。结果表明,亚基的大小和形状的微小差异会导致微剂量测定结果的相当大的差异。本研究中提出的模型提供了一个幻影,它不仅呈现了肾元的真实几何形状,这在以前的程式化模型中被忽略了,而且还具有绘制肾元细胞中放射性药物的任何分布的吸收剂量的空间分布的能力。
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来源期刊
AIMS Biophysics
AIMS Biophysics BIOPHYSICS-
CiteScore
2.40
自引率
20.00%
发文量
16
审稿时长
8 weeks
期刊介绍: AIMS Biophysics is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers in the field of biophysics. We publish the following article types: original research articles, reviews, editorials, letters, and conference reports. AIMS Biophysics welcomes, but not limited to, the papers from the following topics: · Structural biology · Biophysical technology · Bioenergetics · Membrane biophysics · Cellular Biophysics · Electrophysiology · Neuro-Biophysics · Biomechanics · Systems biology
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