Misleading Report on Artesunate Resistance

N. Valecha
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Abstract

Artemsinin resistance is defined as a delayed clearance after treatment with an artemsinin-based combination therapy or artesunate [1]. The case reported in the article does not meet the WHO classification. It is not specified if the patient was positive at day 3 and if any K13 mutation (marker of artemisinin resistance) was detected at day 0. It is also not clear whether at day of failure it was new infection or recrudescence since details of genotyping are not given. Finally the patient responded to ACT with a rapid clearance of parasitaemia within 24 hours which is not in favour of artemisinin resistance
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关于青蒿琥酯耐药性的误导性报告
青蒿素耐药被定义为在以青蒿素为基础的联合治疗或青蒿琥酯治疗后出现的延迟清除。文章中报告的病例不符合世卫组织的分类。没有具体说明患者在第3天是否呈阳性,以及在第0天是否检测到任何K13突变(青蒿素耐药性标志)。由于没有给出基因分型的细节,也不清楚失败当天是新感染还是复发。最后,患者对联合治疗有反应,寄生虫血症在24小时内迅速清除,这不利于对青蒿素产生耐药性
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