{"title":"Biosynthesis of monodispersed silver nanoparticles and their activity against Mycobacterium tuberculosis","authors":"A. Banu, V. Rathod","doi":"10.4172/2155-983X.1000110","DOIUrl":null,"url":null,"abstract":"Tuberculosis (TB) is a life threatening disease, caused by Mycobacterium tuberculosis. Emergence of high degree of drug-resistance and prevalence of Mycobacterium other than tuberculosis (MOTT) necessitates the search for new anti-tubercular agents. In that context, silver nanoparticles (AgNPs) which have been known for their antimicrobial activity were evaluated against clinical isolates of M. tuberculosis Multi-Drug Resistant (MDR), Extensive-Drug Resistant (XDR) and MOTT strains, through Microplate Alamar Blue Assay (MABA). All the clinical isolates got inhibited within the MIC range of 6.25 to 12.5 μg/ml of AgNPs. Silver nanoparticles were synthesized by bioreduction of silver nitrate (AgNO3) solution with enzymes extracted from R. stolonifer and characterized using UV-Vis absorption spectrophotometry, FTIR, XRD, AFM. A spherical shaped AgNPs with the average particle size of 5 nm were synthesized and evaluated for their antimycobacterial activity.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"3 1","pages":"211"},"PeriodicalIF":0.0000,"publicationDate":"2013-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"42","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of biomedical nanoscience and nanotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2155-983X.1000110","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 42
Abstract
Tuberculosis (TB) is a life threatening disease, caused by Mycobacterium tuberculosis. Emergence of high degree of drug-resistance and prevalence of Mycobacterium other than tuberculosis (MOTT) necessitates the search for new anti-tubercular agents. In that context, silver nanoparticles (AgNPs) which have been known for their antimicrobial activity were evaluated against clinical isolates of M. tuberculosis Multi-Drug Resistant (MDR), Extensive-Drug Resistant (XDR) and MOTT strains, through Microplate Alamar Blue Assay (MABA). All the clinical isolates got inhibited within the MIC range of 6.25 to 12.5 μg/ml of AgNPs. Silver nanoparticles were synthesized by bioreduction of silver nitrate (AgNO3) solution with enzymes extracted from R. stolonifer and characterized using UV-Vis absorption spectrophotometry, FTIR, XRD, AFM. A spherical shaped AgNPs with the average particle size of 5 nm were synthesized and evaluated for their antimycobacterial activity.
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