“A comparative evaluation of the effects of different commercially available denture adhesives on the growth of Candida species in diabetic and nondiabetic subjects:” An In vivo Study

Abstract

Purpose: Denture patients should use denture adhesives cautiously. Difficulty in maintaining good oral hygiene can be caused by the presence of a thick deposit of adhesive which may act as a reservoir of Candida albicans. In diabetic condition, chances of infections are more. Therefore, this study was carried out to investigate the effects of different commercially available denture adhesives on the growth of Candida species in diabetic and nondiabetic patients. Materials and Methods: Sixty edentulous subjects were divided into two main groups and six subgroups based on diabetes and use of three denture adhesives. The swab sample and nonstimulated saliva were collected at the time of denture insertion and 14 days after use of the adhesives. Microbiological procedures were carried out following the same. The data collected in terms of colony forming unit and colony forming unit per milliliter (CFU and CFU/ml) was subjected to statistical analysis. Results: Intra- and inter-group comparison showed no significant difference to exist for both test and control group (CG); although, there was a minimal increase in the number of CFU/ml of Candida species at 14 days. Interpretation and Conclusion: There was an overall increase in the number of CFU/ml of Candida species following the use of denture adhesives in CG and test groups and after 14 days of use of denture adhesive. The mean percentage increase in CFU/ml was not of any clinical significance.