{"title":"Structure-Activity Relationship of Two Typical Amaryllidaceae Isocarbostyril Alkaloids and their Derivatives","authors":"Yubin Ji, Yan Dong, N. Chen, D. Song, Jia Zheng","doi":"10.4028/www.scientific.net/AMM.411-414.3158","DOIUrl":null,"url":null,"abstract":"This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.","PeriodicalId":12383,"journal":{"name":"食品与药品","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4028/www.scientific.net/AMM.411-414.3158","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"食品与药品","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.4028/www.scientific.net/AMM.411-414.3158","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This paper reviews the structure-activity relationship of two typical Amaryllidaceae isocarbostyril alkaloids, narciclasine, pancratistatin and their derivatives. Varieties structures have important impacts on biological activity of Amaryllidaceae isocarbostyril alkaloids, for example, the nuclear structure of isocarbostyril, the stereochemistry of the B/C ring junction, the C7-hydroxy of ring A, hydroxies of ring C and so on. This study is conducive to find other active groups, conduct structural modifications and provide the rational basis for designing drugs molecular.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
