Impact of Śodhana (Ayurvedic purification process) on thrombolytic effect of Semecarpus anacardium Linn. f. Nut

D. Sarvade, K. Bhingardive, M. Jaiswal
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Abstract

Aims and Objectives: In vitro evaluation and comparison of thrombolytic activity of raw and purified bhallātaka (Semecarpus anacardium Linn.f.) nuts by means of % of clot lysis. Materials and Methods: An in vitro thrombolytic model was used to check the clot lysis effect of two aqueous preparations of herbal extracts viz. raw and purified bhallātaka nuts along with Streptokinase as a positive control and distilled water as a negative control. Results: Among the drugs studied both raw and purified bhallātaka nuts showed significant percentage of clot lysis viz. 59.82% and 66.59% respectively with reference to Streptokinase whose percentage was 87.31%. Clot lysis percentage of purified bhallātaka was highest as compared to raw bhallātaka and was comparable to positive control, i.e. streptokinase. Conclusion: Extremely significant difference (P < 0.0001) between mean clot lysis percentage of tested drug samples was found as compared to positive control streptokinase and negative control distilled water. Both raw and purified bhallātaka nuts showed extremely significant mean clot lysis percentage as compared to negative control distilled water (P < 0.001).
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Śodhana(阿育吠陀纯化工艺)对无心半腕果溶栓作用的影响。f。螺母
目的和目的:用凝块溶解率的方法评价和比较生的和纯化的bhallātaka(半核桃)坚果的溶栓活性。材料与方法:采用体外溶栓模型,以链激酶为阳性对照,蒸馏水为阴性对照,考察两种植物提取物(bhallātaka坚果)的溶栓效果。结果:所研究的药物中,bhallātaka坚果的凝块溶解率分别为59.82%和66.59%,而链激酶的凝块溶解率为87.31%。与原bhallātaka相比,纯化bhallātaka的凝块溶解率最高,与阳性对照(即链激酶)相当。结论:与阳性对照链激酶和阴性对照蒸馏水相比,检测药物样品的平均凝块溶解率差异极显著(P < 0.0001)。与阴性对照蒸馏水相比,生的和纯化的bhallātaka坚果的平均凝块溶解率都非常显著(P < 0.001)。
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