Aesculus indica: An ethnomedicinal, phytochemical, and pharmacological review

Som K. Madhvi, J. Iqbal, M. Younis, Himachal Pradesh. In, Himachal Pradesh
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Abstract

Aesculus indica , commonly known as Indian horse chestnut, is an indigenous tree of the family Sapindaceae, distributed in Nepal, India, Pakistan, and Afghanistan. As an ethnomedicine, its seeds are used to cure jaundice, chest diseases, stomach and joint pain, roots for leucorrhea, and bark for fever and anaemia. The phytochemicals of class phenolic, triterpenoid, glycoside, saponin, and fatty acid have been identified from their different parts and various biological activities such as antioxidant, anti-diabetic, hypocholesterolemic, hypoglycaemic, anti-nociceptive, anti-inflammatory, neuro-depressive, spasmolytic, immunomodulatory, anticancer, enzyme inhibitory, antimicrobial and insecticidal have been reported, which reflected its medicinal importance. However, most biological activities are on the extracts or fractions and need more in-depth study. Therefore, further research is required on the isolation, identification, and characterization of active phytochemicals from the extracts with their mechanism of pharmacological action and detailed toxicological evaluation. In this review, we aim to provide all information regarding traditional uses, morphology, phytochemistry, pharmacology, and toxicity of A. indica and address the research gaps; therefore, will provide a source of information to the researchers for further studies.
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七叶神:民族医药、植物化学和药理学综述
七叶树(Aesculus indica),俗称印度七叶树,是一种本土树种,分布在尼泊尔、印度、巴基斯坦和阿富汗。作为一种民族药,它的种子用于治疗黄疸,胸部疾病,胃和关节疼痛,根用于白带,树皮用于发烧和贫血。从不同部位鉴定出酚类、三萜类、糖苷类、皂苷类、脂肪酸类等植物化学物质,并报道了其抗氧化、降糖尿病、降胆固醇、降血糖、抗伤害、抗炎、神经抑制、解痉、免疫调节、抗癌、抑酶、抗菌、杀虫等多种生物活性,反映了其药用价值。然而,大多数生物活性都在提取物或馏分上,需要更深入的研究。因此,从提取物中分离、鉴定和表征活性植物化学物质,并对其药理作用机制和详细的毒理学评价进行进一步的研究。在本文中,我们旨在提供有关印楝的传统用途、形态、植物化学、药理和毒性的所有信息,并弥补研究空白;因此,将为研究人员的进一步研究提供信息来源。
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来源期刊
CiteScore
1.00
自引率
12.50%
发文量
1
审稿时长
52 weeks
期刊介绍: Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.
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