Synthesis of Dihydroxamic Acids from Dinitrones, Structural Characterization and Antimicrobial Activities

IF 0.6 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Journal of the chemical society of pakistan Pub Date : 2022-01-01 DOI:10.52568/001004/jcsp/44.02.2022
Cherifa Mahieddine Cherifa Mahieddine, Said Zerkout Said Zerkout, Sidali Rayane Sidali Rayane, Houssam Boulebd Houssam Boulebd, Affaf Laassami Affaf Laassami, Salah Akkal Salah Akkal
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Abstract

The benefits of dinitrones (N,Nand#39;-Diphenyl-2,5-thenylenedinitrone, N,Nand#39;-Dimethyl-1,4-phenylenedinitrone and N,Nand#39;-Dibenzyl-1,4-phenylenedinitrone) in the synthesis were chosen as simple process for synthesis of the purified dihydroxamic acid compounds in a shorter time with a good yield and high purity without need to purification. The most stable conformers of the synthesized compounds and their electronic properties have been determined using DFT/B3LYP calculations. Antimicrobial activity assessment of dihydroxamic acids showed their good efficiency.
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二硝基酮合成二羟肟酸、结构表征及抗菌活性
利用二硝基酮(N,Nand#39;-二苯基-2,5-苯基丁二酮,N,Nand#39;-二甲基-1,4-苯基丁二酮)在合成中的优势,以较短的时间合成纯化的二羟肟酸化合物,收率好,纯度高,无需提纯。利用DFT/B3LYP计算确定了合成化合物的最稳定构象及其电子性质。二羟肟酸的抑菌活性评价表明其抑菌效果良好。
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来源期刊
CiteScore
1.30
自引率
14.30%
发文量
41
审稿时长
3.4 months
期刊介绍: This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.
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