Pub Date : 2023-01-01DOI: 10.52568/001191/jcsp/45.01.2023
Fengying Chen Fengying Chen, YouYing Di and Guochun Zhang YouYing Di and Guochun Zhang
A novel complex [Ni(C10H8O5N3)2]and#183;H2Oand#183;(CH3OH) (1) (C10H9O5N3= 2-[(4-nitro- benzoyl)-hydrazone]-propionic acid) has been prepared by reaction of NiCl2 with C10H9O5N3 in mixed solvent of methanol and water. The Ni(II) complex in octahedral geometry was characterized by elemental analysis and X-ray single crystal diffraction. Isothermal titration calorimetry (ITC) was performed to observe the reactions between Ni(II) and C10H9O5N3 in methanol solvents. The results showed that the binding constant (Ka), enthalpy change (ΔH), entropy change (ΔS), and Gibbs free energy change (ΔG) of the system are 5.2and#215;105, -11.82 kJand#183;mol-1, 69.78 Jand#183;mol-1and#183;K-1 and -32.62 kJand#183;mol-1, respectively. In addition, the structure was optimized and frontier molecular orbital (FMO) of (1) were analyzed by B3LYP and HF methods with 6-31g level.
{"title":"Crystal Structure, Theoretical Analyses and Thermodynamic Properties of a Ni(II) Complex Based on ONO Donor Tridentate Acylhydrazone","authors":"Fengying Chen Fengying Chen, YouYing Di and Guochun Zhang YouYing Di and Guochun Zhang","doi":"10.52568/001191/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001191/jcsp/45.01.2023","url":null,"abstract":"A novel complex [Ni(C10H8O5N3)2]and#183;H2Oand#183;(CH3OH) (1) (C10H9O5N3= 2-[(4-nitro- benzoyl)-hydrazone]-propionic acid) has been prepared by reaction of NiCl2 with C10H9O5N3 in mixed solvent of methanol and water. The Ni(II) complex in octahedral geometry was characterized by elemental analysis and X-ray single crystal diffraction. Isothermal titration calorimetry (ITC) was performed to observe the reactions between Ni(II) and C10H9O5N3 in methanol solvents. The results showed that the binding constant (Ka), enthalpy change (ΔH), entropy change (ΔS), and Gibbs free energy change (ΔG) of the system are 5.2and#215;105, -11.82 kJand#183;mol-1, 69.78 Jand#183;mol-1and#183;K-1 and -32.62 kJand#183;mol-1, respectively. In addition, the structure was optimized and frontier molecular orbital (FMO) of (1) were analyzed by B3LYP and HF methods with 6-31g level.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001199/jcsp/45.01.2023
X. B. L. X B Lu, N. X. L. N X Li, T. W. J. T W Jie, Q. Q. X. A. Z. Y. Q Q Xu and Z Yang
Herein, we report four self-assembly Iron(II/III) complex consisting triethanolamine (TEOA) as ligand and an FeIII(TPA)Cl3 (TPA= 3-(2-pyridine methyl) amine) as contrast catalyst, for photochemical reduction of CO2 to CO under visible light. The photocatalytic systems were assembled by [Ru(bpy)3]Cl2 as photosensitizer, and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo-[d]-imidazole (BIH) as electron donor. Experiments are conducted to study the relationship between CO production and the external ions. Different external counterions are provided to assist the discussion of the influence of these external ions on catalysis. Density functional theory calculations confirmed that the external ions have an effect on the CO yield. Moreover, a mechanism involving proton-coupled electron transfer is proposed.
{"title":"Photocatalytic System using Iron-Based Catalysts: Effect of External Ions on CO2-to-CO Conversion","authors":"X. B. L. X B Lu, N. X. L. N X Li, T. W. J. T W Jie, Q. Q. X. A. Z. Y. Q Q Xu and Z Yang","doi":"10.52568/001199/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001199/jcsp/45.01.2023","url":null,"abstract":"Herein, we report four self-assembly Iron(II/III) complex consisting triethanolamine (TEOA) as ligand and an FeIII(TPA)Cl3 (TPA= 3-(2-pyridine methyl) amine) as contrast catalyst, for photochemical reduction of CO2 to CO under visible light. The photocatalytic systems were assembled by [Ru(bpy)3]Cl2 as photosensitizer, and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo-[d]-imidazole (BIH) as electron donor. Experiments are conducted to study the relationship between CO production and the external ions. Different external counterions are provided to assist the discussion of the influence of these external ions on catalysis. Density functional theory calculations confirmed that the external ions have an effect on the CO yield. Moreover, a mechanism involving proton-coupled electron transfer is proposed.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001244/jcsp/45.03.2023
Li Ran Li Ran, Deng Yunli Deng Yunli, Wu Siliang Wu Siliang, Liao Jiayi Liao Jiayi, Tang Xiujuan Tang Xiujuan, Han Xiaoxiang Han Xiaoxiang
A series of organic-exchanged silicotungstic acid catalysts were synthesized by changing the variety and amount of organic compounds. The structure, thermal stability and acidic properties of the catalysts were characterized by FT-IR, XRD, TGA and 31P-MAS NMR. The catalytic performances of the catalysts were investigated on the selective esterification of lauric acid with glycerol to glycerol monolaurate. Among the various catalysts, [QuH]1H3SiW12O40 with molar ratio of quinoline to silicotungstic acid of 1:1 showed excellent activity and reusability due to strong Brand#248;nsted acidity and “pseudo-liquid” catalytic modes. The optimal conditions optimized by response surface methodology were as follows: the molar ratio of glycerol to lauric acid was 5.3:1, the amount of catalyst was 4.8 wt%, the reaction temperature was 424 K, and the reaction time was 1.5 h. Under these conditions, the average yield of glycerol monolaurate was 79.7%, which was basically consistent with the values predicted by the mathematical model. Moreover, the kinetic data of this reaction were fitted to a second-order kinetic model and the apparent activation energy Ea was 52.35 kJ / mol
{"title":"Organic-Exchanged Silicotungstic Acid Compounds as Efficient and Environmental-Friendly Catalysts for Synthesis of Glycerol Monolaurate","authors":"Li Ran Li Ran, Deng Yunli Deng Yunli, Wu Siliang Wu Siliang, Liao Jiayi Liao Jiayi, Tang Xiujuan Tang Xiujuan, Han Xiaoxiang Han Xiaoxiang","doi":"10.52568/001244/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001244/jcsp/45.03.2023","url":null,"abstract":"A series of organic-exchanged silicotungstic acid catalysts were synthesized by changing the variety and amount of organic compounds. The structure, thermal stability and acidic properties of the catalysts were characterized by FT-IR, XRD, TGA and 31P-MAS NMR. The catalytic performances of the catalysts were investigated on the selective esterification of lauric acid with glycerol to glycerol monolaurate. Among the various catalysts, [QuH]1H3SiW12O40 with molar ratio of quinoline to silicotungstic acid of 1:1 showed excellent activity and reusability due to strong Brand#248;nsted acidity and “pseudo-liquid” catalytic modes. The optimal conditions optimized by response surface methodology were as follows: the molar ratio of glycerol to lauric acid was 5.3:1, the amount of catalyst was 4.8 wt%, the reaction temperature was 424 K, and the reaction time was 1.5 h. Under these conditions, the average yield of glycerol monolaurate was 79.7%, which was basically consistent with the values predicted by the mathematical model. Moreover, the kinetic data of this reaction were fitted to a second-order kinetic model and the apparent activation energy Ea was 52.35 kJ / mol","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The petroleum ether soluble and insoluble fractions of the methanol extract of air dried stem extract of Daphne mucronata and a pure compound daphnin obtained from the more active petroleum ether insoluble fraction were evaluated for the pro-neurogenic activity on cortical and hippocampal primary cell cultures prepared from the neonatal mice brain. It showed significant proliferation of the cells as assessed by MTT assay
{"title":"Pro-Neurogenic Potential of Daphne mucronata Royle","authors":"Perveen Bano Perveen Bano, Kanwal Iftikhar Kanwal Iftikhar, Kinza Rafi Kinza Rafi, Bina Shaheen Siddiqui Bina Shaheen Siddiqui, Shabana Usman Simjee Shabana Usman Simjee, Sabira Begum Sabira Begum","doi":"10.52568/001249/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001249/jcsp/45.03.2023","url":null,"abstract":"The petroleum ether soluble and insoluble fractions of the methanol extract of air dried stem extract of Daphne mucronata and a pure compound daphnin obtained from the more active petroleum ether insoluble fraction were evaluated for the pro-neurogenic activity on cortical and hippocampal primary cell cultures prepared from the neonatal mice brain. It showed significant proliferation of the cells as assessed by MTT assay","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001194/jcsp/45.01.2023
Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif
Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.
{"title":"Cholinesterase Inhibiting Terpenoid from Albizia kalkora","authors":"Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif","doi":"10.52568/001194/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001194/jcsp/45.01.2023","url":null,"abstract":"Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70707604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pesticide residues on fruits and vegetables are of major health concern around the world. Some of these pesticide residues are extremely toxic and can become a major causative factor for various diseases such as cardiovascular disorders (CVDs), lung, endocrine, and nervous system damage, as well as the circulatory system, and reproductive system problems. This study was aimed at investigating the effectiveness of saponins isolated from alfalfa (Medicago sativa L.) seeds for mitigating cypermethrin residues on apples (Malus domestica Borkh.) in comparison to tap water, citric acid, and baking soda. Cypermethrin concentration applied to apples was 1 ml/L. After washing the apples with varying concentrations of different washing solutions, analysis for cypermethrin residues was performed using a UV/VIS spectrophotometer at a wavelength of 535 nm. The maximal removal of residues recorded for baking soda, tap water, and citric acid was 92.98, 72.50, and 74.59 % respectively. Saponins exhibited a maximum of 13.90 % of residual removal which was not as effective as other washing agents.
{"title":"Assessing the Effectiveness of Saponins from Alfalfa (Medicago sativa L.) to Mitigate Cypermethrin Residues in Apples","authors":"Soban Manzoor Soban Manzoor, Waqas Asghar Waqas Asghar, Rao Sanaullah Khan Rao Sanaullah Khan, Nauman Khalid Nauman Khalid","doi":"10.52568/001197/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001197/jcsp/45.01.2023","url":null,"abstract":"Pesticide residues on fruits and vegetables are of major health concern around the world. Some of these pesticide residues are extremely toxic and can become a major causative factor for various diseases such as cardiovascular disorders (CVDs), lung, endocrine, and nervous system damage, as well as the circulatory system, and reproductive system problems. This study was aimed at investigating the effectiveness of saponins isolated from alfalfa (Medicago sativa L.) seeds for mitigating cypermethrin residues on apples (Malus domestica Borkh.) in comparison to tap water, citric acid, and baking soda. Cypermethrin concentration applied to apples was 1 ml/L. After washing the apples with varying concentrations of different washing solutions, analysis for cypermethrin residues was performed using a UV/VIS spectrophotometer at a wavelength of 535 nm. The maximal removal of residues recorded for baking soda, tap water, and citric acid was 92.98, 72.50, and 74.59 % respectively. Saponins exhibited a maximum of 13.90 % of residual removal which was not as effective as other washing agents.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70707711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001198/jcsp/45.01.2023
Amna Kamal Amna Kamal, Muhammad Adnan Iqbal Muhammad Adnan Iqbal, Haq Nawaz Bhatti and Abdul Ghaffar Haq Nawaz Bhatti and Abdul Ghaffar
Alkyl-substituted azolium salts (1-8) and their Se-N-heterocyclic carbene (Se-N-Het-C) adducts (9-12) were obtained in very reasonable yields. All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and elemental analysis. It was found that all synthesized Se-N-Het-C adducts were stable at room temperature in both air and moisture. In-vitro these compounds (5-12) were assessed for their antimicrobial potential against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis), and Bacillus cereus (B. cereus) in vitro. Results of MIC and inhibition zone values revealed that the majority of the Selenium N-Heterocyclic carbene adducts were active against Bacillus subtilis (B. subtilis) than Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) whereas opposite in the azolium salts (5-8). Compounds 5-8 have an inhibition zone of 16and#177;0.1-26and#177;0.3mm against all tested bacterial strains while selenium-NHC adducts 9-12 have a zone of inhibition (16and#177;0.2 to 25 and#177; 0.4mm). Adduct 12 showed good activity against all tested strains with ZI values 25 and#177; 0.1, 22and#177; 0.5, 17 and#177; 0.3 mm and MIC values 17 and#177; 0.2, 16 and#177; 0.4 and 18 and#177; 0.3 and#181;g/mL against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) respectively. Adduct 10 showed the highest thrombolysis i-e 86.9% and adduct 12 showed good hemolysis i-e 0.51%. Overall results of thrombolysis and cytotoxicity studies revealed that the compounds are safe for preclinical studies of mouse blood in vitro.
{"title":"Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts","authors":"Amna Kamal Amna Kamal, Muhammad Adnan Iqbal Muhammad Adnan Iqbal, Haq Nawaz Bhatti and Abdul Ghaffar Haq Nawaz Bhatti and Abdul Ghaffar","doi":"10.52568/001198/jcsp/45.01.2023","DOIUrl":"https://doi.org/10.52568/001198/jcsp/45.01.2023","url":null,"abstract":"Alkyl-substituted azolium salts (1-8) and their Se-N-heterocyclic carbene (Se-N-Het-C) adducts (9-12) were obtained in very reasonable yields. All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and elemental analysis. It was found that all synthesized Se-N-Het-C adducts were stable at room temperature in both air and moisture. In-vitro these compounds (5-12) were assessed for their antimicrobial potential against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis), and Bacillus cereus (B. cereus) in vitro. Results of MIC and inhibition zone values revealed that the majority of the Selenium N-Heterocyclic carbene adducts were active against Bacillus subtilis (B. subtilis) than Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) whereas opposite in the azolium salts (5-8). Compounds 5-8 have an inhibition zone of 16and#177;0.1-26and#177;0.3mm against all tested bacterial strains while selenium-NHC adducts 9-12 have a zone of inhibition (16and#177;0.2 to 25 and#177; 0.4mm). Adduct 12 showed good activity against all tested strains with ZI values 25 and#177; 0.1, 22and#177; 0.5, 17 and#177; 0.3 mm and MIC values 17 and#177; 0.2, 16 and#177; 0.4 and 18 and#177; 0.3 and#181;g/mL against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) respectively. Adduct 10 showed the highest thrombolysis i-e 86.9% and adduct 12 showed good hemolysis i-e 0.51%. Overall results of thrombolysis and cytotoxicity studies revealed that the compounds are safe for preclinical studies of mouse blood in vitro.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70707794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A novel superabsorbent composite (SAC) based on bentonite, acrylamide and acrylic acid was synthesized. The effects of bentonite quantity, initiator content on the grafting degree and on the water absorbency for the samples were studied. Synthesis mechanism, morphology and thermal properties of the SAC were characterized. FTIR results confirmed the presence of acrylamide/ acrylic acid onto bentonite backbone while TGA showed that introduction of 70 % bentonite to polymer increases thermal stability. The SAC was also tested in the removal of heavy metal in aqueous solution where kinetics analyses were performed using Langmuir adsorption isotherm. The optimum adsorption capability of heavy metal ions onto bentonite-based SAC from solution was 92, 48 and 91 % for Pb++, Ni++, and Cu++ respectively. The unique characteristics of these SAC such as its slow-release and water-retention capability, nontoxicity in soil, environmentally friendly and high capacity for the removal of heavy metals might be very valuable in agriculture and environmental studies
{"title":"Synthesis, Characterization and Application of Karak Bentonite Clay-Graft-Poly (Acrylamide/Co- Acrylic Acid) Superabsorbent Composite and its Adsorption Study for Selected Heavy Metals","authors":"Shaheen Wali Shaheen Wali, Manzoor Iqbal Khattak Manzoor Iqbal Khattak, Mahmood Iqbal Khattak and Ashif Sjjad Mahmood Iqbal Khattak and Ashif Sjjad","doi":"10.52568/001240/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001240/jcsp/45.03.2023","url":null,"abstract":"A novel superabsorbent composite (SAC) based on bentonite, acrylamide and acrylic acid was synthesized. The effects of bentonite quantity, initiator content on the grafting degree and on the water absorbency for the samples were studied. Synthesis mechanism, morphology and thermal properties of the SAC were characterized. FTIR results confirmed the presence of acrylamide/ acrylic acid onto bentonite backbone while TGA showed that introduction of 70 % bentonite to polymer increases thermal stability. The SAC was also tested in the removal of heavy metal in aqueous solution where kinetics analyses were performed using Langmuir adsorption isotherm. The optimum adsorption capability of heavy metal ions onto bentonite-based SAC from solution was 92, 48 and 91 % for Pb++, Ni++, and Cu++ respectively. The unique characteristics of these SAC such as its slow-release and water-retention capability, nontoxicity in soil, environmentally friendly and high capacity for the removal of heavy metals might be very valuable in agriculture and environmental studies","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001246/jcsp/45.03.2023
Fatma A M Mohamed Fatma A M Mohamed, Bi Bi Zainab Mazhari Bi Bi Zainab Mazhari, Mona F Warrad Mona F Warrad, Hesham A M Gomaa Hesham A M Gomaa, Asmaa T Ali Asmaa T Ali, Shaimaa Salah Eldeen Hussein and Hendawy Om Shaimaa Salah Eldeen Hussein and Hendawy Om
The reaction of β-dicarbonyl compounds as ethyl acetoacetate with hydrazines is a well-established route for the creation of pyrazole derivatives. In this research, 4-hydrazinoquinazoline (4) reacted with ethyl acetoacetate in boiling ethanol it gives ethyl 3-oxobutanoate quinazolin-4-yl-hydrazone (5). Cyclization of the compound (5) in the presence of glacial acetic acid is passed to form 4-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)quinazoline(6). Furthermore, the reaction of phenylisothiocyanate compounds with hydrazines is a well-established way for the synthesis of tetrazinoquinazoline (8). The new compounds are confirmed by elemental analysis, nuclear magnetic resonance, infrared, and mass spectra. In-vitro anti-tumor evaluation of the new compounds across three cell lines HepG2 (liver carcinoma), HCT-116 (colon carcinoma), and MCF-7 (breast carcinoma) indicats high anti-tumor activity. In addition, antimicrobial activity of specific synthesized compounds are screened against four bacterial species. Amongst four, two Gram-negative are Escherichia coli, Pseudomonas aeuroginosa and gram-positive as Staphylococcus aureus and Bacillus subtilis. The antibacterial activity of Compounds (5) and (6) are greater comparing to standard drug (Amphicillin).
{"title":"Synthesis, Characterization, Antimicrobial and Anticarcinogenic Activity of Quinazoline Derivatives","authors":"Fatma A M Mohamed Fatma A M Mohamed, Bi Bi Zainab Mazhari Bi Bi Zainab Mazhari, Mona F Warrad Mona F Warrad, Hesham A M Gomaa Hesham A M Gomaa, Asmaa T Ali Asmaa T Ali, Shaimaa Salah Eldeen Hussein and Hendawy Om Shaimaa Salah Eldeen Hussein and Hendawy Om","doi":"10.52568/001246/jcsp/45.03.2023","DOIUrl":"https://doi.org/10.52568/001246/jcsp/45.03.2023","url":null,"abstract":"The reaction of β-dicarbonyl compounds as ethyl acetoacetate with hydrazines is a well-established route for the creation of pyrazole derivatives. In this research, 4-hydrazinoquinazoline (4) reacted with ethyl acetoacetate in boiling ethanol it gives ethyl 3-oxobutanoate quinazolin-4-yl-hydrazone (5). Cyclization of the compound (5) in the presence of glacial acetic acid is passed to form 4-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)quinazoline(6). Furthermore, the reaction of phenylisothiocyanate compounds with hydrazines is a well-established way for the synthesis of tetrazinoquinazoline (8). The new compounds are confirmed by elemental analysis, nuclear magnetic resonance, infrared, and mass spectra. In-vitro anti-tumor evaluation of the new compounds across three cell lines HepG2 (liver carcinoma), HCT-116 (colon carcinoma), and MCF-7 (breast carcinoma) indicats high anti-tumor activity. In addition, antimicrobial activity of specific synthesized compounds are screened against four bacterial species. Amongst four, two Gram-negative are Escherichia coli, Pseudomonas aeuroginosa and gram-positive as Staphylococcus aureus and Bacillus subtilis. The antibacterial activity of Compounds (5) and (6) are greater comparing to standard drug (Amphicillin).","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52568/001288/jcsp/45.04.2023
Sunday Ukanwa and Erkay zg r Sunday Ukanwa and Erkay zg r
Research in nanotechnology has progressed in the last decades, and it is purposeful to explore the applications of biocompatible nanoparticles in general and their anticancer attribute specifically. This study is aimed at examining the cytotoxic effects of biocompatible Northern Cyprus propolis extract of iron oxide nanoparticles (PE-Fe2O3-NPs) on MDA-MB-231 epithelial human breast cancer cell line, in vitro. Propolis extract were used to obtain PE-Fe2O3-NPs and further characterized using several methods like ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, scanning electronic microscopy and X-ray diffraction analysis. The PE-Fe2O3-NPs has a distinctive Surface Plasmon Resonance band at 350 nm. The prepared PE-Fe2O3-NPs had a size of 108 nm by diameter with a zeta potential of +33.9 mV which indicates a good stability of the nanoparticles’ while the size of Fe2O3-NPs was 89.40 nm by diameter. Antibacterial result showed that Fe2O3-NPs has highest Minimum Inhibitory Concentration and Minimum Bactericidal Concentration as compared to PE-Fe2O3-NPs with different concentration of propolis extract as regards the tested microorganisms. This indicates that PE-Fe2O3-NPs possesses a more effective threat to eliminating pathogenic bacteria at lesser dosages, be it Gram-ve or Gram+ve. PE-Fe2O3-NPs effectively halted the spread of MDA-MB-231 cancer cell lines and thus, prove to be commendable for anticancer biomedical uses.
{"title":"Synthesis of Iron oxide Nanoparticle using Propolis from Northern Cyprus and Evaluation of its Antibacterial, Anticancer Potential on MDA-MB 231 cells","authors":"Sunday Ukanwa and Erkay zg r Sunday Ukanwa and Erkay zg r","doi":"10.52568/001288/jcsp/45.04.2023","DOIUrl":"https://doi.org/10.52568/001288/jcsp/45.04.2023","url":null,"abstract":"Research in nanotechnology has progressed in the last decades, and it is purposeful to explore the applications of biocompatible nanoparticles in general and their anticancer attribute specifically. This study is aimed at examining the cytotoxic effects of biocompatible Northern Cyprus propolis extract of iron oxide nanoparticles (PE-Fe2O3-NPs) on MDA-MB-231 epithelial human breast cancer cell line, in vitro. Propolis extract were used to obtain PE-Fe2O3-NPs and further characterized using several methods like ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, scanning electronic microscopy and X-ray diffraction analysis. The PE-Fe2O3-NPs has a distinctive Surface Plasmon Resonance band at 350 nm. The prepared PE-Fe2O3-NPs had a size of 108 nm by diameter with a zeta potential of +33.9 mV which indicates a good stability of the nanoparticles’ while the size of Fe2O3-NPs was 89.40 nm by diameter. Antibacterial result showed that Fe2O3-NPs has highest Minimum Inhibitory Concentration and Minimum Bactericidal Concentration as compared to PE-Fe2O3-NPs with different concentration of propolis extract as regards the tested microorganisms. This indicates that PE-Fe2O3-NPs possesses a more effective threat to eliminating pathogenic bacteria at lesser dosages, be it Gram-ve or Gram+ve. PE-Fe2O3-NPs effectively halted the spread of MDA-MB-231 cancer cell lines and thus, prove to be commendable for anticancer biomedical uses.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70709336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：