Investigation of Acrylamide Based Hydrogels as L-Dopa and L-Tyrosine Drug Release System

Abstract

Acrylamide-based hydrogels exhibit significant volume migration in response to physical and chemical stimuli. These properties make their use as drug delivery systems widespread. In the study, acrylamide-based hydrogel structures were synthesized to be used as two prodrugs known as L-Dopa and L-Tyrosine carrier and release system. Fourier-transform infrared (FTIR) spectroscopy, scanning electron micrography (SEM), Image J program were used to evaluate the structure-property relationship of the synthesized hydrogels and swelling studies were performed. The maximum swelling capacity of the synthesized hydrogel structures was determined as 973.80and#177;12.25 %. The L-Dopa loading on the hydrogel was 69.51and#177;9.64% and the L-Tyrosine loading was 61.37and#177;5.08%. The release behavior of the drugs loaded on the hydrogel was monitored using a UV-vis spectrophotometer at pH 7.4 and λmax 280 nm. Accordingly, it was observed experimentally that 84.21and#177;1.71% of L-Dopa and 75.98and#177;2.69% of L-Tyrosine were released. The study is an alternative release system with the simultaneous release of L-Dopa molecule, which is especially used in the treatment of Parkinsonand#39;s disease, and L-Tyrosine, which plays an important role in the synthesis of L-Dopa.