{"title":"Reversed Phase-HPLC Method for Low Level Quantitation of Dimethyl dibenzylidene Sorbitol","authors":"Abdus Salam Abdus Salam","doi":"10.52568/001127/jcsp/44.05.2022","DOIUrl":null,"url":null,"abstract":"Dimethyl dibenzylidene sorbitol (DMDBS) is one of the most commonly used nucleating agent in polypropylene formulations. In present study, a simple and robust reversed phase liquid chromatography (RP-LC) based analytical method was developed for the quantitative low-level determination of DMDBS. The best separation was achieved on a RP-HPLC column TSK gel G2000 SW, 7.5mm x 30cm, Particle Size 10 and#181;m from TOSOH Bioscience. A 0.05 M NH4AC (pH = 6.6) + 10% ACN solution was used as mobile phase at a flow rate of 1.2 ml/min. UV detection was performed at 216 nm. Retention time was found to be 13.056 min. for DMDBS. The response was a linear function of concentration over the range of 2.00 to 8.00 and#181;g/ml with correlation coefficient of 0.9996 for DMDBS. The LOD and LOQ for DMDBS were found to be 1.00 and#181;g/mL and 2.00 and#181;g/mL respectively. The method is simple, rapid and robust, which is suitable for application in quality control and can also be used for the estimation of DMDBS as a leachable/ extractable from polypropylene (PP) resin and resin products like medical device containers.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the chemical society of pakistan","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.52568/001127/jcsp/44.05.2022","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Dimethyl dibenzylidene sorbitol (DMDBS) is one of the most commonly used nucleating agent in polypropylene formulations. In present study, a simple and robust reversed phase liquid chromatography (RP-LC) based analytical method was developed for the quantitative low-level determination of DMDBS. The best separation was achieved on a RP-HPLC column TSK gel G2000 SW, 7.5mm x 30cm, Particle Size 10 and#181;m from TOSOH Bioscience. A 0.05 M NH4AC (pH = 6.6) + 10% ACN solution was used as mobile phase at a flow rate of 1.2 ml/min. UV detection was performed at 216 nm. Retention time was found to be 13.056 min. for DMDBS. The response was a linear function of concentration over the range of 2.00 to 8.00 and#181;g/ml with correlation coefficient of 0.9996 for DMDBS. The LOD and LOQ for DMDBS were found to be 1.00 and#181;g/mL and 2.00 and#181;g/mL respectively. The method is simple, rapid and robust, which is suitable for application in quality control and can also be used for the estimation of DMDBS as a leachable/ extractable from polypropylene (PP) resin and resin products like medical device containers.
期刊介绍:
This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.