Viktor Ilkei, Kornél Faragó, Zsuzsanna Sánta, M. Dékány, L. Hazai, C. Szántay, G. Kalaus
{"title":"The First Synthesis of Sessiline","authors":"Viktor Ilkei, Kornél Faragó, Zsuzsanna Sánta, M. Dékány, L. Hazai, C. Szántay, G. Kalaus","doi":"10.4236/IJOC.2014.45033","DOIUrl":null,"url":null,"abstract":"Sessiline \nis an alkaloid which is recently isolated from the fruits of Acanthopanax sessiliflorus. The molecule \ncontains two five-membered heterocyclic units joined together by an acylaminocarbinol-ether \ntype bond. Here, we describe the first, simple synthesis of sessiline from 5-hydroxypyrrolidin-2-one and 5-hydroxymethylfurfural, which are prepared from succinimide \nand furfuryl alcohol, respectively. The coupling reaction takes place on moderate \nheating under neat conditions.","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"有机化学国际期刊(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/IJOC.2014.45033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Sessiline
is an alkaloid which is recently isolated from the fruits of Acanthopanax sessiliflorus. The molecule
contains two five-membered heterocyclic units joined together by an acylaminocarbinol-ether
type bond. Here, we describe the first, simple synthesis of sessiline from 5-hydroxypyrrolidin-2-one and 5-hydroxymethylfurfural, which are prepared from succinimide
and furfuryl alcohol, respectively. The coupling reaction takes place on moderate
heating under neat conditions.
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