An Investigation into the Relationship of SUR-1TRPM4 Receptor with Peritumoral Edema in High-Grade Glial Tumors.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Turkish neurosurgery Pub Date : 2024-01-01 DOI:10.5137/1019-5149.JTN.36251-21.4

Tolga Turan Dundar, Mehmet Hakan Seyithanoglu, Ganime Coban, Ismail Yurtsever, Ali Toprak, Mustafa Namık Oztanir

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Abstract

Aim: To investigate the presence of Sur1-Trpm4 receptors in high-grade glial tumors, and their relationship with edema volumes in preoperative magnetic resonance imaging (MRI) sequences.

Material and methods: MRI sections were extracted from T1-weighted (T1W) and T2-weighted (T2W) sequences and fluidattenuated inversion recovery (FLAIR) images. After that, T1W 3D magnetization-prepared rapid gradient echo (MP-RAGE) sequences were taken with and without contrast medium. Tumor and peritumoral edema volumes were calculated in cubic centimeters. Sur1- Trpm4 receptors were studied by immunohistochemical examination of tissue samples. Relationships between data were analyzed using Spearman's correlation coefficient.

Results: In the immunohistochemical examinations, 58% of the samples from patients with high-grade glial tumors were positive for Sur1 and 74% were positive for Trpm4. The volume of tumors was correlated with the volume of peritumoral edema.

Conclusion: The presence of the Sur1-Trpm4 receptor complex in high-grade glial tumors was confirmed. Further preclinical or clinical studies are required to identify and validate the role of Sur1-Trpm4 in glial tumor subgroups.

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SUR-1TRPM4 受体与高级别胶质瘤瘤周水肿关系的研究

目的：研究高级别胶质瘤中Sur1-Trpm4受体的存在及其与术前磁共振成像（MRI）序列中水肿体积的关系：从T1加权（T1W）、T2加权（T2W）序列和流体加权反转恢复（FLAIR）图像中提取磁共振成像切片。然后，在使用或不使用造影剂的情况下，拍摄 T1W 三维磁化预处理快速梯度回波（MP-RAGE）序列。肿瘤和瘤周水肿体积以立方厘米为单位计算。通过对组织样本进行免疫组化检查来研究 Sur1- Trpm4 受体。数据之间的关系使用斯皮尔曼相关系数进行分析：在免疫组化检查中，58%的高级别胶质瘤患者样本中 Sur1 呈阳性，74%的样本中 Trpm4 呈阳性。肿瘤体积与瘤周水肿体积相关：结论：Sur1-Trpm4受体复合物在高级别胶质瘤中的存在已得到证实。需要进一步的临床前或临床研究来确定和验证 Sur1-Trpm4 在胶质瘤亚群中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.